卡前列素氨丁三醇联合缩宫素治疗胎盘早剥产后大出血的临床研究  

Clinical study of the treatment of massive hemorrhage due to placental abruption with carboprost tromethamine and oxytocin

作　　者：王晓婷 WANG Xiao-ting(Zhongshan Minzhong Hospital,Zhongshan 528436,China)

机构地区：[1]广东省中山市民众医院,528436

出　　处：《中国实用医药》2023年第6期21-24,共4页China Practical Medicine

摘　　要：目的 探讨卡前列素氨丁三醇联合缩宫素治疗胎盘早剥产后大出血的临床疗效。方法 66例胎盘早剥产后大出血患者,随机分为对照组和研究组,各33例。对照组接受缩宫素治疗,研究组在对照组治疗基础上运用卡前列素氨丁三醇治疗。比较两组治疗效果、产后出血量、手术前后凝血功能指标及不良反应发生情况。结果 研究组治疗总有效率为93.94%,高于对照组的72.73%,差异有统计学意义(P<0.05)。研究组产后2、12、24 h出血量分别为(215.50±48.50)、(272.50±45.00)、(355.60±55.00)ml,均少于对照组的(325.60±45.00)、(375.00±48.00)、(414.00±60.50)ml,差异有统计学意义(P<0.05)。术后24 h,两组血浆凝血酶原时间(PT)、部分活化凝血活酶时间(APTT)均短于本组术前,纤维蛋白原(FIB)高于本组术前,且研究组PT(11.30±1.10)s、APTT(23.85±3.30)s均短于对照组的(14.30±1.20)、(31.80±4.60)s,FIB(3.90±0.30)g/L高于对照组的(3.60±0.25)g/L,差异有统计学意义(P<0.05)。研究组不良反应总发生率为15.15%,与对照组的21.21%比较,差异无统计学意义(P>0.05)。结论 应用卡前列素氨丁三醇联合缩宫素治疗胎盘早剥产后大出血可以取得确切疗效,有助于为临床研究提供参考依据。Objective To discuss the clinical efficacy of carboprost tromethamine combined with oxytocin in the treatment of massive hemorrhage after placental abruption.Methods A total of 66 patients with postpartum hemorrhage due to placental abruption were randomly divided into a control group and a research group,with 33 patients in each group.The control group received oxytocin therapy,and the research group was treated with carboprost tromethamine on the basis of the control group.The therapeutic effect,amount of postpartum hemorrhage,coagulation index before and after surgery,and the occurrence of adverse reactions were compared between the two groups.Results The total effective rate of treatment in the research group was 93.94%,which was higher than 72.73%in the control group,and the difference was statistically significant(P<0.05).The blood loss at 2,12 and 24 h postpartum in the research group were(215.50±48.50),(272.50±45.00)and(355.60±55.00)ml,which were less than(325.60±45.00),(375.00±48.00)and(414.00±60.50)ml in the control group,and the differences were statistically significant(P<0.05).At 24 h after surgery,the plasma prothrombin time(PT)and activated partial thromboplastin time(APTT)in both groups were shorter than those before surgery in this group,and the fibrinogen(FIB)was higher than that before surgery in this group;the PT(11.30±1.10)s and APTT(23.85±3.30)s in the research group were shorter than(14.30±1.20)and(31.80±4.60)s in the control group;the FIB(3.90±0.30)g/L in the research group was higher than(3.60±0.25)g/L in the control group;the differences were statistically significant(P<0.05).The overall incidence of adverse reactions in the research group was 15.15%,which was not statistically significant when compared with 21.21%in the control group(P>0.05).Conclusion The application of carboprost tromethamine combined with oxytocin in the treatment of postpartum hemorrhage due to placental abruption can achieve a definite effect,which is helpful for clinical research.

关 键 词：产后大出血 胎盘早剥 卡前列素氨丁三醇 缩宫素 凝血功能 

分 类 号：R714.461[医药卫生—妇产科学]