冠状动脉支架植入术后药物洗脱球囊联合切割球囊的疗效  

Effect of drug eluting balloon combined with cutting balloon on in-stent restenosis after coronary artery stenting

作　　者：伍灏堃 樊婷[2] 余天浩[1] 廖文君 李晓伟 WU Haokun;FAN Ting;YU Tianhao;LIAO Wenjun;LI Xiaowei(Department of Cardiology,Guang-dong Provincial People′s Hospital,Guangzhou 510317,China;不详)

机构地区：[1]广东省第二人民医院心内一科,广州510317 [2]广东省第二人民医院院感科,广州510317

出　　处：《实用医学杂志》2023年第3期309-314,共6页The Journal of Practical Medicine

基　　金：广东省医学科研基金项目(编号:B2021227)。

摘　　要：目的 研究冠状动脉支架植入术后药物洗脱球囊联合切割球囊的疗效。方法 采取前瞻性研究,以冠状动脉支架置入手术后发生支架内再狭窄(ISR)(狭窄率≥50%)并于2021年7-12月期间在广东省第二人民医院治疗72例患者作为研究对象,将ISR患者的分为观察组以及对照组,每组36例,观察组患者采取药物洗脱球囊联合切割球囊治疗,对照组患者给予药物洗脱球囊治疗。分析两组的治疗效果、心功能、不良心血管事件之间的差异。结果 经过治疗后,两组患者的血管内径以及狭窄率显著改善(P <0.05),且观察组患者的血管内径显著高于对照组(P <0.05),狭窄率显著低于对照组(P <0.05),经过治疗后,两组患者的LVEF、LAD显著升高(P <0.05),RVD、LVD、LVEDV下降(P <0.05),且观察组患者的LVEF、LAD显著高于对照组(P <0.05),RVD、LVD、LVEDV低于对照组(P <0.05);观察组术后6个月发生复发性心绞痛、非致死性心肌梗死、靶血管血运重建、心力衰竭显著低于对照组(P <0.05)。观察组患者术后的Mb、cTnⅠ显著高于对照组(P <0.05),两组术后6个月Mb、cTnⅠ水平差异无统计学意义(P>0.05)。结论 在对ISR患者进行治疗过程中,采用切割球囊联合联合药物脱洗球囊进行治疗,效果以及预后较好。Objective To study the effect of drug eluting balloon combined with cutting balloon after coronary artery stenting.Methods In this prospective study,we included 72 patients contracting in-stent restenosis(ISR)with a stenosis rate≥50%after coronary artery stenting hospitalized in our hospital during July 2021 and December 2021 and divided them equally into observation group and control group.The patients in the observation group were treated with drug-eluting balloon joint cutting balloon and those in the control group with drug eluting balloon.The two groups were compared in terms of treatment effect,cardiac function and adverse cardiovascular events.Results After treatment,the vascular inner diameter and the stenosis rate among the patients in the two groups were significantly improved(P<0.05).The vascular inner diameter in the observation group was signifi-cantly larger than that in the control group(P<0.05)and the stenosis rate was significantly lower than that in the control group(P<0.05).After treatment,the LVEF and LAD in the two groups were significantly increased(P<0.05),while RVD,LVD and LVEDV were decreased(P<0.05).The LVEF and LAD in the observation group were significantly higher than those in the control group(P<0.05)and RVD,LVD and LVEDV were significantly lower than those of the control group(P<0.05).The incidences of recurrent angina pectoris,non-fatal myocardial infarction,target vessel revascularization and heart failure in the observation group at 6 months after operation were significantly lower than those in the control group(P<0.05).The postoperative Mb and cTnⅠin the observation group were significantly higher than those in the control group(P<0.05).There was no significant difference in the levels of Mb and cTnⅠbetween the two groups 6 months after operation(P>0.05).Conclusion For treating patients with ISR,cutting balloon combined with drug eluting balloon achieves good therapeutic effect and prognosis.

关 键 词：冠状动脉支架植入术 切割球囊 药物脱洗球囊 不良心血管事件 

分 类 号：R459.7[医药卫生—急诊医学]