寿胎丸对肾虚型多囊卵巢综合征不孕患者子宫内膜容受性及相关因子的影响  

Effects of Shoutai Pill on endometrial receptivity and related factors in infertile patients with polycystic ovary syndrome induced by kidney deficiency

作　　者：孙六娜[1] 卢如玲[1] 张淑婷[1] 李安[1] 蓝红云[1] 何艳霞 江湧[1] SUN Liuna;LU Ruling;ZHANG Shuting;LI An;LAN Hongyun;HE Yanxia;JIANG Yong(The First Affiliated Hospital of Guangzhou University of Traditional Chinese Medicine,Guangzhou 510405,China;不详)

机构地区：[1]广州中医药大学第一附属医院,广州510405 [2]广州市番禺区第七人民医院,广州511400

出　　处：《实用医学杂志》2023年第3期355-359,共5页The Journal of Practical Medicine

基　　金：广东省中医药局科研项目(编号:20222048)。

摘　　要：目的 分析寿胎丸对肾虚型多囊卵巢综合征(PCOS)不孕患者子宫内膜容受性及相关因子的影响。方法 前瞻性纳入2020年2月至2022年2月我院收治的肾虚型PCOS不孕患者116例为研究对象,根据信封抽取法将其分为对照组54例、寿胎丸组62例,前者采用来曲唑口服治疗,后者在其基础上联合寿胎丸方剂优化治疗,治疗3个月经周期后对比两组排卵率、妊娠率、卵泡发育情况、子宫内膜容受性、相关因子水平及治疗效果。结果 (1)寿胎丸组治疗后总周期数、排卵率及妊娠率均高于对照组(P <0.05)。(2)寿胎丸组治疗后卵泡直径、成熟卵泡个数及优势卵泡个数均高于对照组(P <0.05)。(3)寿胎丸组治疗后子宫内膜厚度(Em)大于对照组,子宫动脉搏动指数(PI)、子宫动脉血流阻力数(RI)低于对照组(P <0.05)。(4)寿胎丸组治疗后性激素结合球蛋白(SHBG)水平高于对照组(P <0.05);睾酮(T)、黄体生成素(LH)、卵泡生成素(FSH)、内脂素(visfatin)水平低于对照组(P <0.05)。(5)寿胎丸组治疗总有效率高于对照组(P <0.05)。结论 寿胎丸可有效改善肾虚型POCS不孕患者子宫内膜容受性、相关因子水平和卵泡发育情况,提高排卵率及妊娠率。Objective To analyze the effects of Shoutai Pill on endometrial receptivity and the related factors in infertile patients with polycystic ovary syndrome(PCOS)induced by kidney deficiency.Methods A total of 116 infertile patients with PCOS induced by kidney deficiency in our hospital from February 2020 to February 2022 were prospectively included in the study.According to the envelope extraction method,they were divided into control group(54 cases)and Shoutai Pill group(62 cases).Patients in the control group were orally treated with letrozole,and those in the Shoutai Pill group with Shoutai Pill and letrozole.After bejing treated for three menstrual periods,ovulation rate,pregnancy rate,follicular development,endometrial receptivity,the level of related factors and the efficacy of the two groups were compared.Results(1)After treatment,the total number of cycles,the ovulation rate and pregnancy rate of the Shoutai Pill group were higher than those of the control group(P<0.05).(2)The follicle diameter,the number of mature follicles and the number of dominant follicles in the Shoutai Pill group were higher than those in the control group(P<0.05).(3)The endometrial thickness(Em)of the Shoutai Pill group was greater than that of the control group(P<0.05);the uterine artery pulsatility index(PI)and uterine artery resista-nce index(RI)were lower than those of the control group(P<0.05).(4)Serum SHBG level of the Shoutai Pill group was higher than that in the control group(P<0.05),while the serum levels of T,LH,FSH and the visfatin were lower than those of the control group(P<0.05).(4)The total effective rate of the Shoutai Pill group was higher than that of the control group(P<0.05).Conclusion Shoutai Pill can effectively improve endometrial receptivity,the level of related factors and follicular development,and increase vulation rate and pregnancy rate.

关 键 词：寿胎丸 肾虚 多囊卵巢综合征 不孕 子宫内膜容受性 

分 类 号：R271.14[医药卫生—中医妇科学]