脑微透析技术在癫痫中的研究进展  

Progresses in studies of application of brain microdialysis technology in epilepsy

作　　者：李小杰 谭冬 杜玉民 袁宇[1] LI Xiaojie;TAN Dong;DU Yumin;YUAN Yu(Department of Neurosurgery,Affiliated Hospital of Hebei University,Baoding 071000,China)

机构地区：[1]河北大学附属医院神经外科,河北保定071000

出　　处：《实用医学杂志》2023年第3期386-389,394,共5页The Journal of Practical Medicine

基　　金：河北省科技支撑计划项目(编号:162777107D);河北省医学适用技术跟踪项目(编号:GL201654)。

摘　　要：癫痫作为一种常见的的神经系统疾病,具有反复发作和不可预知的特点,单一且常规的监测手段如脑电图对癫痫的预测或治疗指导起到的效果有限,因此结合新的手段可以进一步预测或指导其治疗。脑微透析技术作为一种新兴技术,其能够对大脑中的化学物质浓度等变化进行监测,在一定程度上可以很好地预测癫痫的发作,并且能研究其发生背后的机制,对治疗起到一定指导作用。本文就目前改进时间分辨率的脑微透析技术、微型化取样探针、光遗传学结合脑微透析技术作一综述,旨在为检测癫痫发作中的脑神经化学物质提供新的思路。As a common neurological disease,epilepsy has the characteristics of recurrent seizures and unpredictability.Single and conventional monitoring means,such as EEG,have limited effect on the prediction or treatment guidance of epilepsy.Therefore,the combination of new means can further predict or guide its treatment.As an emerging technology,brain microdialysis technology can monitor changes such as chemical concentration in the brain,which can predict the seizures of epilepsy to a certain extent,and can study the mechanism behind its occurrence,which plays a certain guiding role in treatment.This paper reviews the current brain microdialysis technology,miniaturized sampling probe,optogenetics combined with brain microdialysis technology with improved time resolution,aiming to provide new ideas for the detection of cranial neurochemicals in seizures.

关 键 词：癫痫 脑微透析技术 神经化学物质 

分 类 号：R651.19[医药卫生—外科学]