过氧化亚硝酸盐(ONOO^(-))荧光探针研究进展  

Recent Progress on Peroxynitrite(ONOO^(-))Fluorescent Probes

作　　者：何潞潞 田勇琪 李佳佳[1] 曾竟[1] HE Lu-lu;TIAN Yong-qi;LI Jia-jia;ZENG Jing(College of Chemistry and Chemical Engineering,Xinjiang Normal University,Urumqi 830054,China)

机构地区：[1]新疆师范大学化学化工学院,新疆乌鲁木齐830054

出　　处：《化学试剂》2023年第4期14-24,共11页Chemical Reagents

基　　金：新疆维吾尔自治区自然科学基金项目(2022D01A95);新疆师范大学优秀青年教师科研启动基金项目(XJNU202013)。

摘　　要：过氧化亚硝酸盐(ONOO^(-))是一种重要的活性氧,在生命系统的生理和病理过程中起着至关重要的作用,可以抵抗免疫系统中的外来病菌。但是过量的ONOO^(-)可能会引起许多疾病,甚至是癌症。因此有效的识别和检测ONOO^(-)具有重要意义。近年来由于操作方便、选择性高、可实时性和无创性检测等优势,荧光探针法检测ONOO^(-)的研究得到了快速的发展。基于探针设计原理根据不同的荧光母体进行分类,综述了近五年来用于检测ONOO^(-)荧光探针的研究现状,评述了ONOO^(-)荧光探针的优点和不足,探讨了该领域面临的挑战,展望了ONOO^(-)荧光探针的研究和发展方向,为今后人们研究ONOO^(-)在生理病理过程中的作用提供了一定的参考价值。Peroxynitrite(ONOO^(-))is an important reactive oxygen species that plays a crucial role in the physiological and pathological processes of the living system and is resistant to foreign bacteria in the immune system.However,excessive ONOO^(-)may cause many diseases,or even cancer.Thus the effective identification and detection of ONOO^(-)is of great importance.Recently,the detection of ONOO^(-)by fluorescent probe detection has been rapidly developed due to the advantages of easy operation,high selectivity,real-time,and non-invasive detection.This review paper classified different fluorescent matrix based on probe design principles,summarized the research status of ONOO^(-)fluorescent probes in the past five years,reviewed the advantages and disadvantages of ONOO^(-)fluorescent probes.We would also discuss the challenges faced by this field,the research and development direction of ONOO^(-)fluorescent probe,and provides guidance for the future research on the role of ONOO^(-)in the physiopathological process.

关 键 词：ONOO^(-) 荧光探针 检测 识别 进展 

分 类 号：O657.3[理学—分析化学]