DNA模板荧光金属纳米团簇的合成及应用  

Synthesis of DNA-Templated Metal Nanoclusters and Applications in Biosensing and Bioimaging

作　　者：毛安丽 王海波[2] MAO An-li;WANG Hai-bo(Basic Medical Department,Xinyang Vocational and Technical College,Xinyang 464000,China;College of Chemistry and Chemical Engineering,Xinyang Normal University,Xinyang 464000,China)

机构地区：[1]信阳职业技术学院基础医学部,河南信阳464000 [2]信阳师范学院化学化工学院,河南信阳464000

出　　处：《化学试剂》2023年第4期25-33,共9页Chemical Reagents

基　　金：国家自然科学基金项目(U1704153)。

摘　　要：荧光金属纳米团簇的尺寸介于金属原子和纳米颗粒之间,特殊的结构和尺寸赋予了金属纳米团簇一系列优异的荧光特性,如荧光强度高、抗光漂白性能强、较大的斯托克斯位移。脱氧核糖核酸(DNA)由于其独特的结构和可设计的序列而成为合成金属纳米簇的理想模板。DNA模板的金属纳米簇主要包括DNA模板的银纳米团簇(DNA-AgNCs)、铜纳米团簇(DNA-CuNCs)、金纳米团簇(DNA-AuNCs)等。DNA模板的金属纳米团簇作为一种新型的荧光纳米探针在生物传感和生物成像等领域具有较大潜在应用价值。基于先前对DNA模板的金属纳米团簇的研究,系统总结了DNA模板的金属纳米簇的制备、性质和在生物传感以及生物成像中的应用。最后,讨论了DNA模板的金属纳米簇的未来发展研究重点和前景。The size of fluorescent metal nanoclusters is between metal atoms and nanoparticles.The special structure and size endow fluorescent metal nanoclusters with a series of excellent fluorescence properties,such as strong fluorescence,good anti-photobleaching,and mega-Stokes shift.Deoxyribonucleic acid(DNA)is an ideal template for the synthesis of metal nanoclusters due to its unique structure and designable sequence.The metal nanoclusters of DNA template mainly include silver nanoclusters(DNA-AgNCs),copper nanoclusters(DNA-CuNCs)and gold nanoclusters(DNA-AuNCs).The metal nanocluster of DNA template as a new type of fluorescent nanoprobe has great application potentials in the fields of biosensing and biological imaging.Based on previous studies on DNA-templated metal nanoclusters,we focued on systematical summary of the preparations,property regulations and applications of DNA-templated metal nanoclusters in biosensing and bioimaging.Finally,the current research emphases and prospects of DNA-templated metal nanoclusters were also discussed.

关 键 词：DNA模板荧光金属纳米团簇 DNA模板银纳米团簇 DNA模板铜纳米团簇 DNA模板金纳米团簇 生物传感 生物成像 

分 类 号：O657.39[理学—分析化学]