实验动物在肠道菌群与非酒精性脂肪肝病研究中的应用  

Application of Laboratory Animals in the Study of Intestinal Flora and Nonalcoholic Fatty Liver Disease

作　　者：褚燕青 褚晓峰 CHU Yanqing;CHU Xiaofeng(Laboratory Animal Research Center of Zhejiang Chinese Medical University,Hangzhou 310053,China;High Level Bio-safety Laboratory of Hangzhou Medical College,Hangzhou 310013,China)

机构地区：[1]浙江中医药大学动物实验研究中心,杭州310053 [2]杭州医学院高等级生物安全实验室,杭州310013

出　　处：《实验动物科学》2023年第1期87-92,共6页Laboratory Animal Science

基　　金：国家自然科学基金(31970511);浙江省自然科学基金(LS21C040001)。

摘　　要：非酒精性脂肪肝病(NAFLD)是一种复杂的获得性代谢应激肝损伤疾病,NAFLD的发生发展受遗传、老龄化、生活方式、饮食、中心性肥胖相关的胰岛素抵抗、代谢综合征以及肠道菌群等相关联的并行因素的影响。近年来,人们越来越重视肠道菌群在NAFLD发病机制中的作用。肠道菌群通过多个生理过程对体内肝功能有显著影响,包括能量代谢、肥胖、糖尿病和NAFLD。动物实验提供了有力的证据,表明肠道菌群失调在肥胖症和NAFLD疾病发生发展中发挥了重要作用。本文对实验动物在肠道菌群与非酒精性脂肪肝病研究中的应用进行探讨。Nonalcoholic fatty liver disease(NAFLD)is a complex acquired liver injury disease caused by metabolic stress.The occurrence and development of NAFLD are affected by genetics,aging,lifestyle,diet,central obesity-related insulin resistance,metabolic syndrome,and intestinal flora.Recently,increasing attention has been focused on the role of intestinal flora in NAFLD pathogenesis.Intestinal flora has significant effects on liver functions through multiple physiological processes,including energy metabolism,obesity,type II diabetes,and NAFLD.Animal experiments provide strong evidence that an intestinal flora imbalance plays a major role in the occurrence and development of obesity and NAFLD.Here,we discuss the application of laboratory animals in the study of intestinal flora and NAFLD.

关 键 词：实验动物 肠道菌群 非酒精性脂肪肝病 

分 类 号：Q95-3[生物学—动物学]