T6SS-5 and the cGAS-STING pathway in Burkholderia pseudomallei infection and immunity  

作　　者：Noreafifah Semail Nik Mohd Noor Nik Zuraina Yasmin Khairani Muhammad Ismadi Nurul Iman Mohamad Azian Harun Ismail Aziah Zakuan Zainy Deris 

机构地区：[1]Department of Medical Microbiology and Parasitology,School of Medical Sciences,Universiti Sains Malaysia,16150 Kubang Kerian,Kelantan,Malaysia [2]School of Biology,Faculty of Applied Science,Universiti Teknologi Mara,Shah Alam,40450 Selangor,Malaysia [3]Institute for Research in Molecular Medicine,Universiti Sains Malaysia,16150 Kubang Kerian,Kelantan,Malaysia

出　　处：《Asian Pacific Journal of Tropical Biomedicine》2023年第3期94-103,共10页亚太热带生物医学杂志（英文版）

基　　金：supported by the Ministry of Higher Education Malaysia for Fundamental Research Grant Scheme with Project Code:FRGS/1/2019/SKK11/USM/02/5。

摘　　要：Burkholderia pseudomallei is a causative agent of melioidosis that can infect humans and animals in endemic countries,specifically in Southeast Asia and tropical Australia.A fundamental component for the pathogenesis of Burkholderia pseudomallei is the capability of the bacterium to enter,survive,replicate,and cause disease in a host cell by inducing the host cell fusion.Cell fusion results in multinucleated-giant cell formation,thus enabling the dissemination of Burkholderia pseudomallei intracellularly.cGAS reacts to Burkholderia pseudomallei infection by activating the cGAS-STING pathway and subsequently limiting host's aberrant cell division and cellular replication by inducing autophagic cell death.In this review,we discuss the host-pathogen interactions between the typeⅥsecretion system 5(T6SS-5)of Burkholderia pseudomallei and human cGAS pathway in melioidosis infections.Since T6SS-5 is a main virulent factor in Burkholderia pseudomallei and the c GAS pathway is vital for host immune response,elucidating their functions is important for better understanding the pathogenesis of Burkholderia pseudomallei.

关 键 词：Burkholderia pseudomallei MELIOIDOSIS T6SS-5 c GAS-STING IFN-1 

分 类 号：R392[医药卫生—免疫学]