睾丸素-2在糖尿病肾损伤中的诊断价值  

Diagnostic value of testican-2 in diabetic renal injury

作　　者：陈金玲 黎杨杨 杨丽萍 李爱华 杨立业 CHEN Jinling;LI Yangyang;YANG Liping;LI Aihua;YANG Liye(Department of Clinical Laboratory,Yangjiang Municipal People′s Hospital,Yangjiang,Guangdong 529500,China;Precision Medicine Center,Yangjiang Municipal People′s Hospital,Yangjiang,Guangdong 529500,China)

机构地区：[1]广东省阳江市人民医院检验科,广东阳江529500 [2]广东省阳江市人民医院精准医学中心,广东阳江529500

出　　处：《检验医学与临床》2023年第7期892-894,898,共4页Laboratory Medicine and Clinic

基　　金：广东省阳江市医疗卫生类科技计划项目(SF2021047)。

摘　　要：目的 探讨血清睾丸素-2(testican-2)检测对糖尿病肾损伤的临床诊断价值,为临床寻求高诊断效能的肾损伤标志物打下基础。方法 选择该院2021年5至2022年4月收治的糖尿病患者(排除糖尿病肾病)50例作为糖尿病患者组,同期糖尿病肾病患者65例作为糖尿病肾病患者组,健康体检者50例作为健康对照组。检测所有研究对象的testican-2、胱抑素C(CysC)、β2-微球蛋白(β2-M)、血肌酐(Scr)和尿素氮(BUN)水平,分析testican-2在糖尿病肾损伤中的诊断价值,以及testican-2水平与CysC、β2-M、Scr和BUN之间的相关性。结果 糖尿病肾病患者组血清testican-2水平与健康对照组比较,差异有统计学意义(P<0.05)。testican-2诊断糖尿病肾损伤的曲线下面积为0.707,临界值为10.25 ng/mL时,灵敏度为58.3%,特异度为77.8%。血清testican-2水平与Scr和β2-M水平均呈负相关(P<0.05),相关系数分别为-0.282、-0.250。结论 testican-2在糖尿病肾损伤临床诊断中有一定的临床意义,其水平与传统的肾脏标志物β2-M、Scr均呈负相关。Objective To explore the clinical diagnostic value of serum testican-2 detection in diabetic renal injury to lay a foundation for exploring the renal markers with high diagnostic efficiency.Methods Fifty cases of diabetes(excluding diabetic nephropathy,diabetes group)treated in this hospital from May 2021 to April 2022,contemporaneous 65 cases of diabetic nephropathy(diabetic nephropathy group)and 50 healthy subjects undergoing physical examination(healthy control group)were selected.The levels of testican-2,cystatin C(CysC),β2-microglobulin(β2-M),serum creatinine(Scr)and urea nitrogen(BUN)were detected in all study subjects.The diagnostic value of testican-2 in diabetic kidney injury and the correlation between the testican-2 level with CysC,β2-M,Scr and BUN were analyzed.Results The level of serum testican-2 had statistical difference between the diabetic nephropathy group and healthy control group(P<0.05).The area under the receiver operating characteristic(ROC)curve of testican-2 for diagnosing diabetic nephropathy was 0.707,the critical value was 10.25 ng/mL,the sensitivity was 58.3%and specificity was 77.8%.The serum testican-2 level was negatively correlated with Scr andβ2-M,and the correlation coefficients were-0.282 and-0.250 respectively.Conclusion testican-2 has certain clinical significance in the diagnosis of diabetic renal injury,and its level is negatively correlated with the traditional renal markersβ2-M and Scr.

关 键 词：糖尿病 肾损伤 睾丸素-2 胱抑素C 

分 类 号：R466.11[医药卫生—临床医学]