甲硫氨酸合成酶A2756G基因多态性与冠心病易感性的系统评价与Meta分析  

Polymorphism of methionine synthetase A2756G and susceptibility of coronary artery disease:a systematic review and a Meta-analysis

作　　者：王栋 梁嘉琪 支琳钰 司琪琪 张鑫[4] 许建国 兰赟 Wang Dong;Liang Jiaqi;Zhi Linyu;Si Qiqi;Zhang Xin;Xu Jianguo;Lan Yun(Department of Cardiothoracic Surgery,Zhangye People's Hospital Affiliated to Hexi University,Zhangye 734000,China;不详)

机构地区：[1]河西学院附属张掖人民医院胸外科,张掖734000 [2]西安交通大学第二附属医院心血管内科,西安710004 [3]兰州大学第一临床医学院,兰州730000 [4]甘肃中医药大学第一临床医学院,兰州730000 [5]兰州大学基础医学院循证医学中心,兰州730000

出　　处：《中国循证心血管医学杂志》2023年第1期35-40,共6页Chinese Journal of Evidence-Based Cardiovascular Medicine

摘　　要：目的运用Meta分析的方法探讨甲硫氨酸合成酶(MTR)A2756G基因多态性与冠状动脉粥样硬化性心脏病(冠心病)易感性的关系。方法计算机检索CNKI、万方、维普、PubMed、Corchrane Library、Web of Science数据库,收集MTR A2756G多态性与冠心病易感性相关的病例对照研究。采用RevMan软件对纳入的研究进行统计学分析和异质性检验。结果共纳入病例对照研究23个,其中14个研究样本来源于亚洲人群,3个研究样本来源于欧洲人群,2个研究样本来源于非洲人群。Meta分析结果显示:MTR A2756G GG基因型存在与冠心病易感性较强的相关性:GG vs.AA(OR=1.52,95%CI:1.17~1.97),GG vs.AA+AG(OR=1.46,95%CI:1.14~1.87);分层分析结果显示GG基因型与亚洲人群冠心病易感性相关(OR=1.52,95%CI:1.03~2.24),与欧洲人群冠心病易感性较强(OR=1.61,95%CI:1.01~2.56),与非洲人群冠心病易感性更明显(OR=3.06,95%CI:0.88~10.60)。结论MTR基因A2756G基因多态性与人群冠心病易感性相关,GG基因型可能是冠心病易感的危险因素。Objective To discuss the relationship between polymorphism of methionine synthetase(MTR)A2756G and susceptibility of coronary artery disease(CAD)by using Meta-analysis method.Methods The databases of CNKI,WanFang Data,VIP Database,PubMed,Corchrane Library and Web of Science were retrieved with computer for collecting case-control studies related to MTR A2756G polymorphism and CAD susceptibility.The included studies were given a statistical analysis and heterogeneity test by applying RevMan software.Results There were totally 23 case-control studies included,among them 14 from Asian populations,3 from European populations and 2 from African populations.The results of Meta-analysis showed that genotypes of MTR A2756G were significantly correlated to CAD susceptibility:GG vs.AA(OR=1.52,95%CI:1.17~1.97),GG vs.AA+AG(OR=1.46,95%CI:1.14~1.87).The results of stratification analysis showed that genotype GG was correlated to CAD susceptibility in Asian populations(OR=1.52,95%CI:1.03~2.24),which was significant in European populations(OR=1.61,95%CI:1.01~2.56)and more significant in African populations(OR=3.06,95%CI:0.88~10.60).Conclusion Polymorphism of MTR A2756G is correlated to CAD susceptibility,and genotype GG may be a risk factor of CAD susceptibility.

关 键 词：甲硫氨酸合成酶 基因多态性 冠心病 META分析 

分 类 号：R541.4[医药卫生—心血管疾病]