Gal-3、SFRP5、H-FABP联合检测对冠心病患者预后评估的临床价值  

Clinical value of combined detection of galectin-3,secretory frizzin 5 and heart-type fatty acid-binding protein to prognosis evaluation in patients with coronary heart disease

作　　者：刘闯[1] 闫佩佩[1] 陈雅丽[1] 李向辉[1] Liu Chuang;Yan Peipei;Chen Yali;Li Xianghui(First Affiliated Hospital of Zhengzhou University,Zhengzhou 450000,China;不详)

机构地区：[1]郑州大学第一附属医院,郑州450000

出　　处：《中国循证心血管医学杂志》2023年第1期102-105,共4页Chinese Journal of Evidence-Based Cardiovascular Medicine

摘　　要：目的探讨血清半乳糖凝聚素-3(Gal-3)、分泌型卷曲蛋白5(SFRP5)、心型脂肪酸结合蛋白(H-FABP)联合检测对冠状动脉粥样硬化性心脏病(冠心病)患者预后评估的临床价值。方法选择2020年1月至2022年6月于郑州大学第一附属医院心内科就诊的83例冠心病患者作为病例组,根据冠心病类型将其分为稳定型心绞痛组(n=21),不稳定型心绞痛组(n=45)和心肌梗死组(n=17);根据临床随访,记录心源性死亡、心肌梗死、病变血管再狭窄以及支架血栓等将患者分为预后不良组(n=18)和预后良好组(n=65)。另选择同期我院进行体检的50例健康人群作为对照组,分析两组血清Gal-3、SFRP5、H-FABP水平变化情况及其临床价值。结果病例组患者血清SFRP5水平显著低于对照组,Gal-3、H-FABP水平均显著高于对照组,差异有统计学意义(P<0.05)。稳定型心绞痛组Gal-3、H-FABP水平均显著低于不稳定型心绞痛组和心肌梗死组,SFRP5水平显著高于不稳定型心绞痛组和心肌梗死组。不稳定型心绞痛组Gal-3、H-FABP水平均显著低于心肌梗死组;SFRP5水平显著高于心肌梗死组,差异具有统计学意义(P<0.05)。预后不良组血清SFRP5水平均显著低于预后良好组,Gal-3、H-FABP水平均显著高于预后良好组,差异具有统计学意义(P<0.05)。ROC曲线分析结果显示,血清Gal-3预测冠心病患者不良预后的AUC为0.779,灵敏度为63.43%,特异度为67.40%,截断值为59.54 ng/L。血清SFRP5预测冠心病患者不良预后的AUC为0.963,灵敏度为81.40%,特异度为70.00%,截断值为4.87 mg/L;血清H-FABP预测冠心病患者不良预后的AUC为0.830,灵敏度为73.50%,特异度为69.00%,截断值为17.46 ng/ml,联合检测的特异度、准确度较单独检测更高(P<0.05)。结论冠心病患者血清中Gal-3、SFRP5、H-FABP的表达异常,在冠心病不良预后中具有一定的诊断价值,同时也为靶向药物的治疗提供了新思路。Objective To investigate the clinical value of combined detection of of galectin-3(Gal-3),secretory frizzin 5(SFRP5)and heart-type fatty acid-binding protein(H-FABP)to prognosis evaluation in patients with coronary heart disease(CHD).Methods CHD patients(n=83)were chosen from First Affiliated Hospital of Zhengzhou University from Jan.2020 to June 2022.CHD patients as case group were divided,according to CHD types,into stable angina pectoris group(SAP group,n=21),unstable angina pectoris group(UAP group,n=45)and myocardial infarction group(MI group,n=17).According to clinical follow-up,CHD patients were divided into poor prognosis group(n=18)and good prognosis group(n=65).Meanwhile the healthy persons with physical examinations(n=50)were chosen into control group.The changes and clinical value of levels of Gal-3,SFRP5 and H-FABP were analyzed in 2 groups.Results SFRP5 level was significantly lower and levels of Gal-3 and H-FABP were significantly higher in case group than those in control group(P<0.05).The levels of Gal-3 and H-FABP were significantly lower and SFRP5 level was significantly higher in SAP group than those in UAP group and MI group.The levels of Gal-3 and H-FABP were significantly lower and SFRP5 level was significantly higher in UAP group than those in MI group(P<0.05).SFRP5 level was significantly lower and levels of Gal-3 and H-FABP were significantly higher in poor prognosis group than those in good prognosis group(P<0.05).The results of ROC curve analysis showed that in predicting poor prognosis AUC of serum Gal-3 was 0.779,sensitivity was 63.43%,specificity was 67.40%and cutoff value was 59.54 ng/L,AUC of serum SFRP5 was 0.963,sensitivity was 81.40%,specificity was 70.00%and cutoff value was 4.87 mg/L,and AUC of serum H-FABP was 0.830,sensitivity was 73.50%,specificity was 69.00%and cutoff value was 17.46ng/mL.The specificity and accuracy of combined detection of Gal-3,SFRP5 and H-FABP were higher than those of single detection of Gal-3,SFRP5 or H-FABP(P<0.05).Conclusion The abnormal expressio

关 键 词：半乳糖凝聚素-3 分泌型卷曲蛋白5 心型脂肪酸结合蛋白 冠状动脉粥样硬化性心脏病 

分 类 号：R541.4[医药卫生—心血管疾病]