盐酸罂粟碱注射液治疗慢性手指缺血的临床研究  

Clinical research of Papaverine Hydrochloride injection in the treatment of chronic digital ischemia

作　　者：张金霞 孙岩 ZHANG Jin-xia;SUN Yan

机构地区：[1]滨州市第二人民医院药学部,256800 [2]山东第一医科大学附属省立医院血管外科,250021

出　　处：《中国疗养医学》2023年第5期528-532,共5页Chinese Journal of Convalescent Medicine

基　　金：山东省中医药科技发展计划(2019-0303);山东省医药卫生科技发展计划(2018WS273)。

摘　　要：目的探讨盐酸罂粟碱注射液治疗慢性手指缺血(chronic digital ischemia,CDI)的临床效果。方法选取2014年3月至2020年3月于滨州市第二人民医院外科住院治疗的手指缺血患者28例,采用随机数字表随机分为观察组和对照组。除基础治疗外,观察组予盐酸罂粟碱注射液肌肉注射治疗,对照组予等体积生理盐水肌注治疗。对比两组患者治疗前后的疼痛评分、患指指掌侧固有动脉血流动力学参数、患指温度和随访期内再入院情况。结果两组患者性别、年龄、体质量指数、病程、合并高血压人数、合并冠心病人数、合并房颤人数、有吸烟史人数等方面比较,差异无统计学意义(P>0.05);治疗前,两组患者收缩期峰值流速、舒张末期流速、平均血流速度、搏动指数、阻力指数、疼痛评分、患指温度组间比较,差异无统计学意义(P>0.05);治疗后,两组患者收缩期峰值流速、舒张末期流速、平均血流速度较治疗前均有显著改善,差异有统计学意义(P<0.05);观察组患者收缩期峰值流速、舒张末期流速、平均血流速度优于对照组,差异有统计学意义(P<0.05);治疗后两组患者搏动指数和阻力指数无显著改变,组间比较差异无统计学意义(P>0.05);治疗后,两组患者患指温度和疼痛评分较治疗前均有显著改善,差异有统计学意义(P<0.05);观察组患指温度改善优于对照组,差异有统计学意义(P<0.05);两组患者治疗后疼痛评分组间比较差异无统计学意义(P>0.05);随访期内观察组无患者再入院治疗,对照组5人再入院治疗,组间比较差异有统计学意义(P<0.05)。结论盐酸罂粟碱注射液可提升缺血手指指掌侧固有动脉的收缩期峰值流速、舒张末期流速和平均血流速度,减轻患指疼痛程度,改善患指的温度。Objective To investigate the clinical effect of Papaverine Hydrochloride injection on chronic digital ischemia.Methods 28 patients with digital ischemia who were hospitalized in Binzhou Second People's Hospital from March 2014 to March 2020 were randomly divided into the observation group and the control group by the random number table.In addition to the basic treatment,the observation group was treated with Papaverine Hydrochloride injection intramuscularly,while the control group was treated with the same volume of normal saline intramuscularly.The pain score,hemodynamic parameters of the palmar proper artery of the affected finger,the temperature of the affected finger and the readmission during the follow-up period were compared between the two groups before and after treatment.Results There was no significant difference between the two groups in sex,age,body mass index,course of disease,number of patients with hypertension,number of patients with coronary heart disease,number of patients with atrial fibrillation,and number of patients with smoking history(P>0.05);Before treatment,there was no statistically significant difference between the two groups in systolic peak velocity,end diastolic velocity,average blood velocity,pulsation index,resistance index,pain score and finger temperature(P>0.05);After treatment,the systolic peak velocity,end diastolic velocity and average blood velocity of the two groups were significantly improved compared with those before treatment(P<0.05);The systolic peak velocity,end diastolic velocity and average blood velocity of the patients in the observation group were better than those in the control group(P<0.05);After treatment,the pulsatile index and resistance index of patients in the two groups did not change significantly,and there was no statistically significant difference between the two groups(P>0.05);After treatment,the temperature and pain score of the affected fingers in the two groups were significantly improved compared with those before treatment(P<0.05);The temp

关 键 词：盐酸罂粟碱注射液 慢性手指缺血 血流动力学 

分 类 号：R543[医药卫生—心血管疾病]