益气活血药对黄芪-红花抗脑缺血的作用机制研究进展  

Mechanism of Radix Astragali seu Hedysari-Flos Carthami Combination against Cerebral Ischemia:A Review

作　　者：罗斌 王文瑄 王江[1] 苗琦[1] 朱慧渊[1] 董炳耀 LUO Bin;WANG Wenxuan;WANG Jiang;MIAO Qi;ZHU Huiyuan;DONG Bingyao(Shaanxi University of Chinese Medicine,Xianyang 712046,China;The Second Affiliated Hospital of Xi′an Medical University,Xi′an 710068,China)

机构地区：[1]陕西中医药大学,咸阳712046 [2]西安医学院第二附属医院,西安710068

出　　处：《世界中医药》2023年第2期281-285,290,共6页World Chinese Medicine

基　　金：国家自然科学基金项目(81503491,81874366,81630105)——基于中医方剂配伍理论的丹参与红花组分配伍抗脑缺血再灌注损伤的机制研究;基于药代学与药效学关联的丹参红花多组分(丹红注射液为例)抗脑缺血作用机制研究;基于药物代谢与生物效应关联的补阳还五汤类方与缺血性中风气虚血瘀证相关的生物学基础研究。

摘　　要：脑缺血是一种突然起病的脑血液循环障碍性疾病,其发病率,死亡率和致残率相对较高,严重影响人类的生命健康及生命质量。脑缺血的发病机制复杂多样,主要涉及炎症反应、氧化应激和兴奋性氨基酸毒性等。中药黄芪-红花是经典的益气活血药对,具有抗炎、抗栓、抑制细胞凋亡等抗脑缺血效应,临床疗效确切。然而,黄芪、红花及其组分配伍抗脑缺血的作用机制鲜有研究。Cerebral ischemia is a condition that occurs suddenly when there isn′t enough blood flow to the brain to meet metabolic demand,with high incidence,mortality,and disability rate,threatening human life quality and even life.The pathogenesis of this disease is complex,involving inflammatory response,oxidative stress,and toxicity of excitatory amino acid.The typical qi-replenishing and blood-activating Radix Astragali seu Hedysari-Flos Carthami pair exerts anti-inflammatory,antithrombus,and apoptosis-inhibiting effects in the treatment of cerebral ischemia.However,the mechanism of the pair and their components against cerebral ischemia is rarely studied.

关 键 词：益气活血 黄芪 红花 脑缺血 作用机制 

分 类 号：R242[医药卫生—中医临床基础]