血塞通联合丁苯酞对2型糖尿病合并脑梗死的疗效分析  

Clinical effect of blood plug combined with butylphthalide for type 2 diabetes mellitus patients with cerebral infarction

作　　者：刘珊[1] 闵玺 胡淑国[1] 牛素贞[2] 高会茹 郭伟宾 张力文 LIU Shan;MIN Xi;HU Shuguo(Department of Endocrinology,The Second Hospital of Shijiazhuang,Hebei,Shijiazhuang 050000,China;不详)

机构地区：[1]河北省石家庄市第二医院内分泌科,050000 [2]河北省石家庄市第二医院心内科,050000 [3]河北省石家庄市第二医院神经内科,050000 [4]河北省石家庄市高新区长江社区卫生服务中心检验科 [5]河北医科大学公共卫生学院流行病与卫生统计学教研室、河北省环境与人群健康重点实验室

出　　处：《河北医药》2023年第5期722-725,共4页Hebei Medical Journal

基　　金：河北省自然科学基金(编号:H2020206224);河北省重点研发计划(编号:19277795D);河北省医学科学研究重点课题计划(编号:20181036)。

摘　　要：目的探讨血塞通联合丁苯酞治疗2型糖尿病(T2DM)合并脑梗死的临床效果。方法选取2020年1月至2022年1月内分泌科收治的T2DM合并脑梗死患者90例,采用数字随机表法分为观察组和对照组,每组45例。对照组在常规治疗的基础上给予血塞通注射液,观察组给予血塞通注射液和丁苯酞。比较2组患者疗效、凝血功能、血脂和心肌酶水平及不良反应发生情况。结果观察组总有效率为71.11%明显高于对照组的46.67%(P<0.05)。2组D-二聚体(D-D)水平较治疗前降低(P<0.05);观察组TC、LDL-C和apoB水平较治疗前降低(P<0.05);观察组肌酸激酶(CK)水平较治疗前降低,且低于对照组(P<0.05);2组患者治疗期间不良反应总发生率差异无统计学意义(P>0.05)。结论血塞通联合丁苯酞治疗T2DM合并脑梗死的临床疗效显著,可减轻机体高凝状态,降低血脂和CK水平,且不增加不良反应发生率,有较高的临床应用价值。Objective To explore the clinical effect of blood plug combined with butylphthalide for type 2 diabetes mellitus(T2DM)patients with cerebral infarction(CI).Methods A total of 90 T2DM patients with CI admitted to the Department of Endocrinology from January 2020 to January 2022 were randomized 1∶1 to receive either conventional therapy of blood plug injection(the control group)or blood plug injection+butylphthalide(the observation group).The aim was to compare the coagulation function,blood lipid,myocardial enzyme level.The curative effect and adverse reaction were assessed.Results The overall effective rate in the observation group was higher than that in the control group(71.11%vs 46.67%,[P<0.05],respectively).D-dimer(D-D)in groups was decreased after treatment(P<0.05).The total cholesterol(TC),low density lipoprotein cholesterol(LDL-C),apolipoprotein B(ApoB)in the observation group were decreased(P<0.05).The creatine kinase(CK)in the observation group was decreased,which was lower relative to the control group(P<0.05).The difference was not statistically significant in adverse reactions between groups(P>0.05).Conclusion For T2DM patients with CI,blood plug combined with butylphthalide has significant clinical effect,which can alleviate the hypercoagulable state,reduce the levels of blood lipid,CK,and adverse reactions,it has high clinical application value.

关 键 词：2型糖尿病 脑梗死 血塞通 丁苯酞 心肌酶 

分 类 号：R587.1[医药卫生—内分泌]