不同的抑酸药联合奥曲肽对肝硬化并发消化道出血疗效的影响  

Effect of Different Antacids Combined with Octreotide on Gastrointestinal Bleeding in Cirrhosis

作　　者：张莉[1] 吴凤丽 ZHANG Li;WU Feng-li(Xinxiang Central Hospital,Henan Xinxiang 453300)

机构地区：[1]新乡市中心医院,河南新乡453300

出　　处：《深圳中西医结合杂志》2023年第3期73-76,共4页Shenzhen Journal of Integrated Traditional Chinese and Western Medicine

摘　　要：目的:探究不同的抑酸药联合奥曲肽对肝硬化并发消化道出血疗效的影响。方法:选取新乡市中心医院2020年5月至2022年5月治疗的80例肝硬化并发消化道出血患者,随机分为观察组和对照组,其中对照组40例采用奥美拉唑治疗,观察组40例采用奥美拉唑+艾普拉唑治疗。评估两组患者临床疗效、治疗情况、不良反应。结果:观察组患者的总有效率高于对照组,差异具有统计学意义(P<0.05);观察组患者再出血率低于对照组,差异具有统计学意义(P<0.05);观察组患者的住院时间、止血时间短于对照组,差异具有统计学意义(P<0.05);观察组患者不良反应发生率低于对照组,差异具有统计学意义(P<0.05)。结论:奥美拉唑+艾普拉唑联合奥曲肽治疗肝硬化并发消化道出血患者具有良好的疗效,能缩短患者的住院治疗时间,减少患者的出血量和再出血率,能减少胃酸的分泌,安全性相对较高,不易引发不良反应。Objective To explore the effects of different antacids combined with octreotide on gastrointestinal bleeding in patients with liver cirrhosis.Methods A total of 80 patients with liver cirrhosis complicated with gastrointestinal bleeding treated in Xinxiang Central Hospital from May 2020 to May 2022 were randomly divided into an observation group and a control group.40 cases in the control group were treated with omeprazole,and 40 cases in the observation group were treated with omeprazole plus ilaprazole.The clinical efficacy,treatment and adverse reactions of the two groups were evaluated.Results The total effective rate of the observation group was higher than that of the control group,the difference was statistically significant(P<0.05).The rebleeding rate of the observation group was lower than that of the control group,and the difference was statistically significant(P<0.05).The hospitalization time and hemostasis time of the observation group were shorter than those of the control group,and the differences were statistically significant(P<0.05).The incidence of adverse reactions in the observation group was lower than that in the control group,and the difference was statistically significant(P<0.05).Conclusion Omeprazole+Eprrazole combined with octreotide has good efficacy in the treatment of patients with cirrhosis complicated with digestive tract bleeding,which can shorten the duration of hospitalization,reduce the amount of blood loss and rebleeding rate of patients,and reduce the secretion of gastric acid,with relatively high safety and not easy to cause adverse reactions.

关 键 词：肝硬化 消化道出血 奥美拉唑 艾普拉唑 奥曲肽 

分 类 号：R657.3+1[医药卫生—外科学]