鸢尾素介导运动干预神经精神疾病的潜在机制  

Potential Mechanism of Irisin-Mediated Exercise's Intervention in Neuropsychiatric Diseases

作　　者：章森 邹勇[1,2] 漆正堂 刘微娜[1,2] ZHANG Sen;ZOU Yong;QI Zhengtang;LIU Weina(Key Laboratory of Adolescent Health Assessment and Exercise Intervention of Ministry of Education,East China Normal University,Shanghai 200241,China;College of Physical Education and Health,East China Normal University,Shanghai 200241,China)

机构地区：[1]华东师范大学青少年健康评价与运动干预教育部重点实验室,上海200241 [2]华东师范大学体育与健康学院,上海200241

出　　处：《上海体育学院学报》2023年第4期39-50,共12页Journal of Shanghai University of Sport

基　　金：国家自然科学基金项目(31871208);上海市自然科学基金项目(18ZR1412000)。

摘　　要：围绕鸢尾素介导运动干预神经精神疾病的最新研究进展,系统梳理鸢尾素通过作用于中枢神经系统促进产生神经营养因子、改善神经元功能、促进神经元增殖和神经发生、改善脑内能量代谢和氧化应激水平、降低神经毒性作用等功能,从外周途径阐述鸢尾素信号通路在运动改善抑郁症、阿尔茨海默病、帕金森综合征等神经精神疾病中的作用机制。发现鸢尾素在运动改善神经精神疾病中起着积极的调控作用,运动诱导的鸢尾素水平会随运动强度的不同而发生改变。肌肉与脑存在着一种以内分泌为主导的通路,骨骼肌作为一种内分泌器官可调控大脑健康和稳态,鸢尾素信号通路可介导运动对神经精神疾病的干预。运动引起的骨骼肌收缩产生的鸢尾素通过外周途径调控大脑的脑源性神经营养因子(BDNF)水平,进而对情绪、认知及神经功能发挥调控作用。The recent research advances around irisin-mediated exercise intervention in neuropsychiatric disorders are presented.The functions of irisin in promoting the production of neurotrophic factors,improving neuronal function,promoting neuronal proliferation and neurogenesis,improving energy metabolism and oxidative stress levels in the brain,and reducing neurotoxic effects by acting on the central nervous system are systematically reviewed.Furthermore,the mechanism of action of irisin signaling pathway in exercise to improve neuropsychiatric disorders such as major depressive disorder,Alzheimer's disease and Parkinson's syndrome was explained from the peripheral pathway.It was found that irisin plays a positively regulatory role in improving neuropsychiatric diseases,and the irisin level induced by exercise varies with the intensity of exercises.There exists an endocrine pathway between muscles and brain,in which the skeletal muscle as an endocrine organ can regulate the health and homeostasis of the brain,and the signaling pathway of irisin may mediate the physical exercise's intervening in neuropsychiatric diseases.The irisin,produced by the exercised-induced skeletal muscle's contraction,may regulates the BDNF level of the brain,which further exerts a vital role in the regulation of emotion,cognition and neurological functions.

关 键 词：鸢尾素 运动 神经精神疾病 肌肉因子 神经保护 

分 类 号：G804.2[文化科学—运动人体科学]