不同内膜准备方案对薄型子宫内膜冻融胚胎移植的影响  

The Effects of Different Endometrial Preparation Protocols on Frozen-Thawed Embryo Transfer in Patients with Thin Endometrium

作　　者：祁晓晨[1] 王晓瑾[1] 惠燕[1] 叶红[1] Qi Xiaochen;Wang Xiaojin;Hui Yan;Ye Hong(Department of Center of Reproductive Medicine,Yichang Central People's Hospital,The First College of Clinical Medical Science,China Three Gorges University,Yichang 443003,China)

机构地区：[1]三峡大学第一临床医学院[宜昌市中心人民医院]生殖医学中心,湖北宜昌443003

出　　处：《巴楚医学》2023年第1期40-45,共6页Bachu Medical Journal

基　　金：湖北省自然科学基金项目(No:2014CFB687)。

摘　　要：目的:探讨不同内膜准备方案对薄型子宫内膜患者冻融胚胎移植(FET)临床结局的影响。方法:回顾性分析2015年10月-2020年3月在我院生殖中心接受FET治疗的薄型内膜患者,据方案不同分三组:A组为改良的自然周期、B组为激素替代周期、C组为诱导排卵周期,比较患者基本情况、用药特征、临床结局等。结果:基本情况方面,B组的既往移植失败次数低于A组和C组(P<0.05)。周期特征方面,与A组和C组相比,B组内膜转化日雌二醇水平、转化时月经周期天数更高,转化日促黄体生成素水平更低(均P<0.05)。临床结局方面,三组间临床妊娠率、着床率、活产率差异无统计学意义(均P>0.05)。结论:对于接受FET治疗的薄型内膜患者,尽管改良的自然周期组和诱导排卵周期组患者的既往移植失败次数高于激素替代周期组,但三组间的的临床结局比较无明显差异。改良的自然周期和诱导排卵周期方案应用于薄型内膜FET治疗可能较激素替代周期方案更有优势。Objective: To investigate the effect of different endometrial preparation protocols on the clinical outcome of thin endometrium patients during the frozen-thawed embryo transfer(FET) cycle. Methods: A retrospective analysis was performed on infertile women with thin endometrium who were treated with FET in our center from October 2015 to March 2020. The patients were divided into three groups, including group A with modified natural cycle, group B with hormone replacement cycle and group C with ovulation induction cycle. The basic clinical information, medication regimen, clinical outcomes were investigated. Results: The times of transplant failure of group B was lower than that of group A and group C(both P<0.05). Compared to the group A and group C, serum estradiol level and the day of menstrual cycle on the transfer day were higher, but serum luteinizing hormone level was lower in the group B(all P<0.05). There was no significant difference in clinical pregnancy rate, implantation rate and live birth rate among these three groups(all P>0.05). Conclusion: For the thin endometrium patients during FET cycle, although the times of transplant failure of modified natural cycle and ovulation induction cycle group were higher than that of the hormone therapy cycle group, there was no significant difference in clinical outcomes among these three groups. Modified natural FET cycle and ovulation induction cycle may tend to be better to hormone replacement cycle for thin endometrial FET treatment.

关 键 词：薄型子宫内膜 冻融胚胎移植 改良的自然周期 激素替代周期 诱导排卵周期 

分 类 号：R711.6[医药卫生—妇产科学]