负压辅助闭合技术与负压封闭引流技术治疗糖尿病足溃疡的效果  

Curative effect of VAC and VSD on diabetic foot ulcers

作　　者：姬正丽[1] 陈增军[1] 张姗姗[1] JI Zhengli;CHEN Zengjun;ZHANG Shanshan(Department of Endocrinology,The First Affiliated Hospital of Henan University of Science and Technology,Luoyang 471003,China)

机构地区：[1]河南科技大学第一附属医院内分泌科,河南洛阳471003

出　　处：《包头医学院学报》2023年第4期39-42,50,共5页Journal of Baotou Medical College

基　　金：洛阳市科技攻关计划项目(1920014A)。

摘　　要：目的:研究负压辅助闭合技术(VAC)与负压封闭引流技术(VSD)两种负压治疗模式治疗糖尿病足溃疡的效果。方法:选取2020年10月至2022年1月期间118例糖尿病足溃疡患者,随机分为VAC组和VSD组,各59例,VAC组予以VAC治疗,VSD组予以VSD治疗。比较治疗后两组创面愈合效果、创面愈合时间、住院时间、换药次数,7 d后肉芽组织覆盖率、细菌清除率、创面缩小率;治疗前后组织氧分压变化、琥珀酸脱氢酶(SDH)和乳酸脱氢酶(LDH)水平、足背动脉血流速度。结果:治疗后VAC组创面愈合效果、组织氧分压、足背动脉血流速度、SDH、肉芽组织覆盖率、细菌清除率、创面缩小率均高于VSD组(P<0.05);VAC组创面愈合时间、住院时间短于VSD组(P<0.05);VAC组换药次数少于VSD组(P<0.05);VAC组LDH浓度低于VSD组(P<0.05)。结论:相较于VSD,VAC用于糖尿病足溃疡创面时愈合效果更佳,能够更有效地提高组织氧分压,可有效缩短住院时间,减少换药次数,促进足背动脉血液循环。Objective:To study the curative effect of vacuum-assisted closure(VAC)and vacuum sealing drainage(VSD)on diabetic foot ulcers.Methods:A total of 118 patients with diabetic foot ulcers were enrolled between October 2020 and January 2022.They were randomly divided into VAC group(VAC)and VSD group(VSD),59 cases in each group.The wound healing effect after treatment,wound healing time,hospitalization time,times of dressing changes,coverage rate of granulation tissues,bacterial clearance rate and wound reduction rate after 7 d,changes in tissue partial pressure of oxygen,succinic dehydrogenase(SDH),lactate dehydrogenase(LDH)and blood flow velocity of dorsalis pedis artery before and after treatment were compared between the two groups.Results:After treatment,wound healing effect,tissue partial pressure of oxygen,blood flow velocity of dorsalis pedis artery,SDH,coverage rate of granulation tissues,bacterial clearance rate and wound reduction rate in VAC group were higher than those in VSD group(P<0.05),wound healing time and hospitalization time were shorter than those in VSD group(P<0.05),times of dressing changes were fewer than those in VSD group(P<0.05),and LDH was lower than that in VSD group(P<0.05).Conclusion:Compared with VSD,VAC has better wound healing effect in diabetic foot ulcers,which can more effectively increase tissue partial pressure of oxygen,effectively shorten hospitalization time,reduce times of dressing changes and promote the blood circulation of dorsalis pedis artery.

关 键 词：负压辅助闭合技术 负压封闭引流技术 糖尿病足溃疡 组织氧分压 足背动脉血流速度 

分 类 号：R587.2[医药卫生—内分泌] R658.3[医药卫生—内科学]