血清迁移率蛋白-1、白细胞介素-6水平与结肠癌患者淋巴结转移的相关性  

Correlation of Serum Mobility Protein-1 and Interleukin-6 Levels with Lymph Node Metastasis in Patients with Colon Cancer

作　　者：左浩 刘业六[1] 李祥伟 马天恒[2] ZUO Hao;LIU Ye-liu;LI Xiang-wei(Department of General Surgery,Huai’an First Hospital Affiliated to Nanjing Medical University,Huai’an Jiangsu,223000,China)

机构地区：[1]南京医科大学附属淮安第一医院普外科,江苏淮安223000 [2]南京医科大学附属淮安第一医院消化内科,江苏淮安223000

出　　处：《黑龙江医学》2023年第6期656-658,662,共4页Heilongjiang Medical Journal

摘　　要：目的:探讨血清迁移率蛋白-1(HMGB-1)、白细胞介素-6(IL-6)与结肠癌患者淋巴结转移的相关性,为临床提供依据。方法:选取2018年7月—2020年6月南京医科大学附属淮安第一医院收治的93例结肠癌患者作为研究对象。所有患者入院后完善有关检查,根据患者是否发生淋巴结转移分为发生组(35例)与非发生组(58例)。选择同期健康体检者67例设为对照组。采用酶联免疫吸附试验测定各组HMGB-1、IL-6水平,分析HMGB-1、IL-6在结肠癌患者淋巴结转移不同病理下的表达,并对结肠癌患者血清HMGB-1、IL-6水平与淋巴结转移完成相关性分析。结果:结肠癌患者淋巴结转移HMGB-1、IL-6与肿瘤直径、病理类型、肿瘤分期比较,差异有统计学意义(t=8.957、7.112;F=7.135、6.993;t=8.453、7.104,P<0.05);多因素logistic回归分析结果表明:肿瘤分期、病理类型、肿瘤直径均为结肠癌患者淋巴结转移的危险因素(OR=3.582、1.034、1.246,P<0.05);Pearson相关性分析结果表明:结肠癌患者淋巴结转移发生率与血清HMGB-1、IL-6水平呈正相关性(r=0.781、0.683,P<0.05)。ROC曲线结果表明:血清HMGB-1与IL-6联合测定在结肠癌患者淋巴结转移中预测效能高于血清HMGB-1、IL-6检测,差异有统计学意义(P<0.05)。结论:结肠癌淋巴结转移患者血清HMGB-1、IL-6水平较高,能反映肿瘤直径、分期及类型,加强患者血清HMGB-1、IL-6水平测定能预测淋巴结转移。Objective:To investigate the correlation between serum mobility protein-1(HMGB-1),interleukin-6(IL-6)and lymph node metastasis in patients with colon cancer.Methods:93 colon cancer patients admitted to the hospital from July 2018 to June 2020 were selected as the study population.All patients were admitted to the hospital to improve the relevant examination,and were divided into the occurrence group(35 cases)and the non-occurrence group(58 cases)according to whether the patients had lymph node metastasis.A total of 67 cases were selected from the same period of healthy physical examination as the control group.Enzyme-linked immunosorbent assay was used to determine the levels of HMGB-1 and IL-6 in each group.The expression of HMGB-1 and IL-6 in lymph node metastasis of colon cancer patients under different pathologies was analyzed,and the correla⁃tion analysis between serum HMGB-1 and IL-6 levels and lymph node metastasis of colon cancer patients was completed.Re⁃sults:There was a statistically significant difference between lymph node metastasis HMGB-1 and IL-6 and tumor diameter,patho⁃logical type,and tumor stage in patients with colon cancer(t=8.957,7.112;F=7.135,6.993;t=8.453,7.104,P<0.05).The results of multi-factor logistic regression analysis showed that tumor stage,pathological type,and tumor diameter were all risk factors for lymph node metastasis in patients with colon cancer(OR=3.582,1.034,1.246,P<0.05).Pearson correlation analysis showed that the incidence of lymph node metastasis in patients with colon cancer was positively correlated with serum HMGB-1 and IL-6 levels(r=0.781,0.683,P<0.05).The results of ROC curves showed that the predictive efficacy of combined serum HMGB-1 and IL-6 assay was higher than that of serum HMGB-1 and IL-6 assay in lymph node metastasis in colon cancer patients,and the difference was statistically significant(P<0.05).Conclusion:Patients with lymph node metastasis of colon cancer have higher serum HMGB-1 and IL-6 levels,which can reflect the tumor diameter,stage and

关 键 词：血清迁移率蛋白-1 白细胞介素-6 结肠癌 淋巴结转移 相关性 

分 类 号：R65[医药卫生—外科学] R574.62[医药卫生—临床医学]