基于电路-概率理论的对神经电刺激不稳定性的定性分析  

Qualitative Analysis of Instability on Electrical Nerve Stimulation Based on Circuit-Probability Theory

作　　者：余守骏 岳文基 阮越 董鹏 陈支通 李铭源[5] 宋冰 王昊 YU Shoujun;YUE Wenji;RUAN Yue;DONG Peng;CHEN Zhitong;LEE Simon Ming-yuen;SONG Bing;WANG Hao(Shenzhen Institute of Advanced Technology,Chinese Academy of Sciences,Shenzhen 518055,China;The Wellcome-MRC Institute of Metabolic Science,University of Cambridge,Cambridge CB20QQ,UK;Howard Hughes Medical Institute/Janelia Research Campus,Ashburn VA 20147,USA;National Innovation Center for Advanced Medical Devices,Shenzhen 518000,China;State Key Laboratory of Quality Research in Chinese Medicine and Institute of Chinese Medical Sciences,University of Macao,Macao 999078,China)

机构地区：[1]中国科学院深圳先进技术研究院,深圳518055 [2]剑桥大学Wellcome-MRC代谢科学研究所,剑桥CB20QQ [3]霍华德·休斯医学研究所珍利亚研究园区,阿什本VA 20147 [4]国家高性能医疗器械创新中心,深圳518000 [5]澳门大学中华医药研究院中药质量研究国家重点实验室,中国澳门999078

出　　处：《集成技术》2023年第2期20-28,共9页Journal of Integration Technology

基　　金：广东省基础与应用基础研究项目(2019A1515110843,2022A1515011129);深圳市国际合作项目(GJHZ20200731095206018)。

摘　　要：神经电刺激通过影响中枢或外周神经系统,进而治疗某疾病。在实际应用中,神经电刺激响应强度的不稳定性较为棘手,一般认为是由于电刺激扰动了神经轴突的膜电位,造成了神经电刺激强度的不稳定性。然而,由于神经电刺激缺乏宏观可计算模型,其膜电位扰动在电刺激中具体产生何种影响,长期以来未得到有效结论。该研究基于电路-概率理论,对神经电刺激不稳定性进行定性分析,有效地分析了膜电位的扰动对电刺激的影响。实验结果表明,在体实验数据和定性仿真的电流幅值-不稳定性曲线具有高度一致性,说明电路-概率理论可能对电刺激产生的膜电位扰动有较为准确的解释。该研究对神经电刺激的实际应用具有指导性意义。Electrical nerve stimulation is an effective method for certain treatments by affecting the central or peripheral nervous system.The instability of electrical nerve stimulation is a critical problem in clinical practice.It is a widely held view that the mechanism of the instability is that the electrical stimulation disturbs the membrane potential of nerve axons.However,due to the lack of a computable macro model for electrical nerve stimulation,it is difficult to effectively study the specific impact of its membrane potential disturbance on electrical stimulation for a long time.Based on the previously proposed circuit-probability theory,this study qualitatively analyzes the instability of electrical nerve stimulation to effectively research the influence of membrane potential disturbance on electrical stimulation.The results show that the current-instability curve of animal experimental data and qualitative simulation is highly consistent,which further indicates that the circuit-probability theory might explain the membrane potential disturbance caused by electrical stimulation and has instructive significance for the practical application of electrical nerve stimulation.

关 键 词：神经电刺激 电路概率理论 电路仿真 计算模型 

分 类 号：Q189[生物学—神经生物学]