纳米药物制备技术与装备及其在纳米农药中的应用  

Technology and Equipment of Nanomedicine and Its Application on Nanopesticides

作　　者：谢锦珊 滕萱铭 杨铮 付智楠 杨泱泱 赵方 乐园[3] 郭旭虹[2] 朱维平[1] XIE Jinshan;TENG Xuanming;YANG Zheng;FU Zhinan;YANG Yangyang;ZHAO Fang;LE Yuan;GUO Xuhong;ZHU Weiping(School of Pharmacy,East China University of Science and Technology,Shanghai 200237,China;School of Chemical Engineering,East China University of Science and Technology,Shanghai 200237,China;The College of Chemical Engineering,Beijing University of Chemical Technology,Beijing 100029,China)

机构地区：[1]华东理工大学药学院,上海200237 [2]华东理工大学化工学院,上海200237 [3]北京化工大学化学工程学院,北京100029

出　　处：《现代农药》2023年第2期19-27,共9页MODERN AGROCHEMICALS

摘　　要：传统农药的长期不合理使用会导致诸多问题,如加剧环境污染、病虫草害抗性增强、资源消耗增加等,严重制约着我国农业的可持续发展。纳米农药具有粒径小、比表面积大、靶向释放等优势,可有效提高农药使用率,改善药物溶解性和叶面黏附性,从而显著提高农药的药效、安全性和经济性。纳米农药是未来农药发展的趋势,具有广阔的应用前景,但其制备技术及工业化放大仍面临着巨大挑战。本文总结了当前常用的纳米药物制备技术,包括乳化技术、微流控技术、超重力技术和纳米沉淀技术,介绍了制备技术原理及装备特点。这将有助于指导纳米农药的规模化生产,对实现可持续农业和全球粮食安全具有至关重要的意义。The long-term improper use of traditional pesticides can lead to a series of problems,such as aggravated environmental pollution,enhanced resistance to diseases,insect pests and weeds and increased resource consumption,which seriously restrict the sustainable development of agriculture in China.Nanopesticides with small particle size,large specific surface area and targeted release can effectively enhance the utilization efficiency of agrochemicals,reduce the dosage,and improve solubility and foliar adhesion,so as to significantly improve the efficacy,safety and economic value of agrochemicals.Nanopesticides are the trend of pesticide development in the future and have broad application prospects,but their preparation technologies and industrial scale-up still face huge challenges.This review summarizes the current preparation technologies in nanomedicine including emulsification technology,microfluidic technology,high-gravity technology,and nanoprecipitation technology,emphasizing their preparation principles,characteristics and equipments,which will help guide the production of nanopesticides with small particle size,uniform distribution,and good stability.It can effectively promote the innovation and development of nanopesticides,and be of vital significance to achieve sustainable agriculture and global food security.

关 键 词：农业 纳米农药 制备技术 装备 

分 类 号：TQ450[化学工程—农药化工]