Omicron轻型患者发热特征及发热期核酸Ct值对核酸转阴时间的影响  

Fever Characteristics of Mild Cases of Omicron Variant Infection and the Influence of Nucleic Acid Ct Value on the Negative Conversion Time of Nucleic Acid During Fever

作　　者：周敬民 曾邦伟[2] 王敏[1] 傅艳红 郑关毅[3] 傅开龙[3] 林侃[3] ZHOU Jingmin;ZENG Bangwei;WANG Min;FU Yanhong;ZHENG Guanyi;FU Kailong;LIN Kan(Department of Anesthesiology,Fujian Medical University Union Hospital,Fuzhou 350001,China;Department of Infection,Fujian Medical University Union Hospital,Fuzhou 350001,China;Department of Traditional Chinese Medicine,Fujian Medical University Union Hospital,Fuzhou 350001,China)

机构地区：[1]福建医科大学附属协和医院麻醉科,福州350001 [2]福建医科大学附属协和医院院感科,福州350001 [3]福建医科大学附属协和医院中医科,福州350001

出　　处：《福建医科大学学报》2023年第1期22-26,共5页Journal of Fujian Medical University

基　　金：国家中医药管理局第七批全国老中医药专家学术经验继承项目;福建医科大学附属协和医院第五批重点学科建设项目(2022YYZDXK16)。

摘　　要：目的分析新型冠状病毒感染(COVID-19)患者的发热特征及核酸转阴时间的影响因素。方法收集2022年3月27日—5月24日上海世博馆方舱医院收治的356例COVID-19发热患者的临床资料,分析发热的基本特征及核酸转阴时间。结果logistic回归分析显示,年龄、发热时间、发热期ORF 1 ab基因和N基因的Ct值均为核酸转阴时间的影响因子,其中发热期ORF 1 ab基因的Ct值对转阴时间影响的关联性更强。结论Omicron株感染患者的年龄、发热时间、发热期ORF 1 ab基因和N基因的Ct值均为核酸转阴时间的独立影响因子,其中发热期ORF 1 ab基因的Ct值关联性更强,可用于预测患者可能的核酸转阴时间。Objective To analyze the characteristics of fever and factors influencing the negative conversion time of nucleic acid in novel coronavirus(COVID-19)infected patients.Methods The clinical data of 356 COVID-19 infected patients with fever admitted to Shanghai World Expo Shelter Hospital from March 27 to May 24,2022 were collected,and the basic characteristics of fever and the time of nucleic acid negative conversion were analyzed.Results The logistic regression analysis showed that the age,days of fever,Ct value of ORF 1 ab gene during fever period,and Ct value of N gene during fever period were all influencing factors of the nucleic acid negative conversion time,and the Ct value of ORF 1 ab gene during fever period was more related to the negative conversion time than that of N gene.Conclusion The age,days of fever,Ct values of ORF 1 ab gene and N gene during fever period of Omicron variant infected patients were independent influencing factors of the negative conversion time of nucleic acid.Among them,the Ct value of ORF 1 ab gene during fever period was more relevant,which can be used to predict the time for the negative conversion of nucleic acid in patients.

关 键 词：新型冠状病毒感染 核酸转阴时间 Omicron变异株 发热 方舱医院 

分 类 号：R563.1[医药卫生—呼吸系统]