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作 者:唐国柯 文根 刘彦斌 朱亮[1] 李玉才 刘毅 王星[4,5] TANG Guoke;WEN Gen;LIU Yanbin;ZHU Liang;LI Yucai;LIU Yi;WANG Xing(Department of Orthopaedics,Shanghai General Hospital,Shanghai Jiao Tong University School of Medicine,Shanghai 200080;Department of Orthopaedics,Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine,Shanghai 201306;Department of Orthopaedics,Tongren Hospital,Shanghai Jiao Tong University School of Medicine,Shanghai 200336;Beijing National Laboratory for Molecular Sciences,Institute of Chemistry,Chinese Academy of Sciences,Beijing 100190;University of Chinese Academy of Sciences,Beijing 100049,China)
机构地区:[1]上海交通大学医学院附属第一人民医院骨科,上海200080 [2]上海交通大学医学院附属第六人民医院骨科,上海201306 [3]上海交通大学医学院附属同仁医院骨科,上海200336 [4]中国科学院化学研究所北京分子科学国家实验室,北京100190 [5]中国科学院大学,北京100049
出 处:《中华骨与关节外科杂志》2023年第2期185-192,共8页Chinese Journal of Bone and Joint Surgery
基 金:中国博士后科学基金第68批面上项目(2020M683733);上海市长宁区科学技术委员会医疗卫生科研专项课题(CNKW2020Y01)。
摘 要:骨移植被广泛应用于临床以修复骨缺损,目前全球对骨移植的需求非常高,每年至少进行220万次植骨手术。由于创伤、癌症、感染、关节炎等疾病引起的骨缺损不断增多,临床治疗中对骨移植物的需求也持续上升。自体骨移植和同种异体骨植骨是临床治疗骨缺损的常用方法,但慢性炎症、疾病传播和免疫排斥反应的发生阻碍了其发展。在临床迫切需求的驱动下,骨组织工程领域应运而生,组织工程技术修复骨缺损被认为是一种理想方法。骨再生生物材料是一类可以支持骨组织在缺损部位的再生过程,同时在原位降解后能够被新生成的骨组织取代的组织工程支架。近年来,水凝胶、纳米纤维支架、3D打印复合支架等多种形式的骨修复材料已取得重要进展,本文围绕骨再生工程领域研究现状,重点介绍了几种典型的骨缺损修复材料的理化性质和应用前景,为研发新一代组织工程支架用于骨缺损修复的治疗提供新思路。Bone transplantation is widely used for repairing bone defects in clinical practice.Currently bone graft is highly demand with at least 2.2 million times a year all over the world.The need for bone grafts in clinical practice continues to rise as the limitations of traditional therapies and an increase in bone defects due to trauma,cancer,infection and arthritis.Autografts and allografts are commonly used in clinical treatment of bone defects,but chronic inflammation,disease transmission and immune rejection hinder their development.Driven by the urgent clinical needs,the field of bone tissue engineering emerges at the historic moment and has achieved rapid development in the past decades.Tissue engineering technology is considered as an ideal method for repairing bone defects.The goal of a biomaterial is to support the bone tissue regeneration process at the defect site and eventually degrade in situ and get replaced with the newly generated bone tissue.Recently,various forms of bone repair materials such as hydrogel,nanofiber scaffolds and 3D printing composite scaffolds are emerging.In this article the physicochemical properties and prospects of various representative bone defect repair materials were introduced based on current research of bone regeneration engineering which was aimed at providing a new idea for developing a new generation of tissue engineering scaffold for bone defect repair.
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