基于双能量CT痛风石成像分析尿酸盐负荷与心血管疾病发生风险及代谢综合征的相关性  被引量:5

Correlation of urate load with risk of cardiovascular disease and metabolic syndrome based on dual-energy CT gout stone imaging analysis

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作  者:杨丹 赵义[2] 王苇[2] YANG Dan;ZHAO Yi;WANG Wei(Clinical Medical College,Yangzhou University,Jiangsu Province,Yangzhou225001,China;Department of Gerontology,Affiliated Hospital of Yangzhou University,Jiangsu Province,Yangzhou225000,China)

机构地区:[1]扬州大学医学院,江苏扬州225001 [2]扬州大学附属医院影像科,江苏扬州225000

出  处:《中国当代医药》2023年第9期22-27,共6页China Modern Medicine

摘  要:目的基于双能量CT(DECT)痛风石成像分析尿酸盐负荷与心血管疾病(CVD)发生风险及代谢综合征(MetS)的相关性。方法收集2019年6月至2022年3月于扬州大学附属医院行足踝部DECT检查的118例痛风患者临床资料,根据DECT图像将患者分为痛风石阳性组(66例)及痛风石阴性组(52例)。收集入组患者的临床及实验室检查资料。对入组患者进行Framingham风险评分(FRS),得到未来10年CVD发生风险;根据MetS相关指标判断患者是否合并MetS。分析尿酸盐负荷[痛风石体积和血尿酸(SUA)]与未来10年CVD发生风险及MetS的相关性。结果DECT痛风石阳性组的年龄、病程、SUA、高血压患病率、舒张压、FRS评分及未来10年CVD发生风险均高于痛风石阴性组,差异均有统计学意义(P<0.05)。痛风患者MetS患病率为44.9%(53/118);痛风石体积与未来10年CVD发生风险呈正相关(r=0.429,P<0.001),SUA与未来10年CVD发生风险不相关(r=0.004,P=0.977),痛风石体积与MetS组分呈正相关(r=0.348,P=0.004),SUA与MetS组分呈正相关(r=0.256,P=0.038);箱式图显示未来10年CVD发生风险随痛风石体积四分位数的增大呈增高的趋势,且差异有统计学意义(P=0.011),MetS组分在痛风石体积第2、3、4四分位数呈增多的趋势,且差异有统计学意义(P=0.033)。结论痛风石体积是未来10年CVD发生风险的独立影响因素,能够在一定程度上预测远期心血管不良事件,对CVD的一级预防及风险分层具有一定的指导意义;痛风患者MetS发病率高,痛风石体积及SUA均与MetS的组分相关,提示高尿酸盐负荷在MetS中发挥比较重要的作用。Objective The correlation between urate load and risk of cardiovascular disease(CVD)and metabolic syndrome(MetS)was analyzed by dual-energy CT(DECT)gouty imaging.Methods Clinical data of 118 patients with gout who underwent foot and ankle DECT examination in Affiliated Hospital of Yangzhou University from June 2019 to March 2022 were collected.According to DECT images,the patients were divided into a gout positive group(n=66)and a gout negative group(n=52).Clinical and laboratory data of enrolled patients were collected.Framingham risk score(FRS)was used to obtain the risk of CVD in the next 10 years.Based on MetS related indicators,the patients were judged to have combined MetS.The association of urate load(gouty volume and blood uric acid[SUA])with CVD risk and MetS in the next 10 years was analyzed.Results The age,course of disease,SUA,prevalence rate of hypertension,diastolic blood pressure,FRS score and risk of CVD in the next 10 years in DECT gouhite positive group were higher than those in gouhite negative group,with statistical significance(P<0.05).The prevalence of MetS in gout patients was 44.9%(53/118);Tophore volume was positively correlated with the risk of CVD in the next 10 years(r=0.429,P<0.001),SUA was not correlated with the risk of CVD in the next 10 years(r=0.004,P=0.977),and tophore volume was positively correlated with MetS components(r=0.348,P=0.004).SUA was positively correlated with MetS(r=0.256,P=0.038).The box chart showed that the risk of CVD in the next 10 years showed an increasing trend with the increase of the volume quartile of turgout,and the difference was statistically significant(P=0.011).MetS components showed an increasing trend in the second,third and fourth quartile of the volume of turgout,and the difference was statistically significant(P=0.033).Conclusion Gout stone volume is an independent influencing factor for the risk of CVD occurrence in the next 10 years,can predict long-term cardiovascular adverse events to a certain extent,and has certain guiding significance fo

关 键 词:双能量CT 痛风 心血管疾病 代谢综合征 

分 类 号:R445.3[医药卫生—影像医学与核医学]

 

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