中药抗肝损伤机制的研究进展  

Research progress on the mechanism of traditional Chinese medicine protecting liver injury

作　　者：孙宜斌 朱铭星 刘跃洋 赵若玮 黄鸣清[1] 程再兴[1] 郑燕芳[1] 林彦翔 SUN Yibin;ZHU Mingxing;LIU Yueyang;ZHAO Ruowei;HUANG Mingqing;CHENG Zaixing;ZHENG Yanfang;LIN Yanxiang(College of Pharmacy,Fujian University of Traditional Chinese Medicine,Fujian Province,Fuzhou350100,China;College of Traditional Chinese Medicine,Fujian University of Traditional Chinese Medicine,Fujian Province,Fuzhou 350122,China;College of Acupuncture and Moxibustion,Fujian University of Traditional Chinese Medicine,Fujian Province,Fuzhou350122,China)

机构地区：[1]福建中医药大学药学院,福建福州350122 [2]福建中医药大学中医学院,福建福州350122 [3]福建中医药大学针灸学院,福建福州350122

出　　处：《中国医药导报》2023年第9期38-40,45,共4页China Medical Herald

基　　金：国家自然科学基金面上项目(81973437、82274080);福厦泉国家自主创新示范区协同创新平台专项项目(2021FX02);福建省“雏鹰计划”青年拔尖人才项目。

摘　　要：肝损伤的发病率逐年上升,亟须研发高质量保肝药物。中药在肝脏保护中具有独特的优势与潜力,对化学、药物、酒精、免疫等多种原因引起的肝损伤均有治疗作用。中药通过提高肝脏抗氧化能力、抑制肝细胞凋亡、调控肝细胞自噬、调节肝代谢、改善肝脏炎症等方面缓解肝损伤。其作用于Nrf2、PI3K、TGF-β1、NF-κB等靶点及相关信号通路,部分药物或活性成分可通过多途径多靶点起效。中药保肝具有良好的应用前景,但存在复方成分繁多,机制交互作用不明的问题,需要更深入的研究为临床应用提供参考。The incidence of liver injury is increasing year by year,it is urgent to develop high quality hepatoprotective drugs.Traditional Chinese medicine has unique advantages and potential in liver protection,and has therapeutic effect in a variety of liver injury caused by chemical,drug,alcohol,and immunity reasons.Traditional Chinese medicine can alleviate liver injury by improving liver antioxidant capacity,inhibiting hepatocyte apoptosis,regulating hepatocyte autophagy,regulating liver metabolism,and improving liver inflammation.It acts on Nrf2,PI3K,TGF-β1,NF-κB and other targets,and related signaling pathways.Some drugs or active ingredients can act through multiple pathways and multiple targets.Traditional Chinese medicine has a good application prospect in liver protection,but there are many components of the compound and unclear mechanism interaction.Further research is needed to provide reference for clinical application.

关 键 词：中药 肝损伤 作用机制 研究进展 

分 类 号：R285[医药卫生—中药学]