固本滋阴汤合益气通络汤治疗老年气阴两虚夹瘀证2型糖尿病周围神经病变患者的效果  

Effect of Guben Ziyin Decoction and Yiqi Tongluo Decoction in treating elderly patients with type 2 diabetes mellitus peripheral neuropathy with syndrome of deficiency of both qi and yin complicated by stasis

作　　者：沈金花[1] 夏静[1] SHEN Jinhua;XIA Jing(Department of Endocrinology,Jiangyin Hospital of Traditional Chinese Medicine,Jiangsu Province,Jiangyin214400,China)

机构地区：[1]江苏省江阴市中医院内分泌科,江苏江阴214400

出　　处：《中国医药导报》2023年第9期80-83,共4页China Medical Herald

基　　金：江苏省干部保健科研项目(BJ19027)。

摘　　要：目的探究固本滋阴汤合益气通络汤对老年气阴两虚夹瘀证2型糖尿病周围神经病变患者的影响。方法选取江苏省江阴市中医院2019年6月至2022年6月接诊的老年气阴两虚夹瘀证2型糖尿病周围神经病变患者83例,采用随机数字表法将其分为甲钴胺组(41例,甲钴胺片)和试验组(42例,甲钴胺组的基础上加用固本滋阴汤合益气通络汤),两组均连续治疗2个月。统计两组治疗前后的中医证候积分、空腹血糖水平、神经传导速度与神经缺陷评分(NDS)。比较两组临床疗效,记录治疗期间的不良反应发生情况。结果治疗后,两组中医证候积分、NDS和空腹血糖水平低于治疗前,腓总神经、正中神经的感觉及运动神经传导速度高于治疗前,且试验组中医证候积分、NDS和空腹血糖水平低于甲钴胺组,腓总神经、正中神经的感觉及运动神经传导速度及均高于甲钴胺组,差异有统计学意义(P<0.05)。试验组疗效优于甲钴胺组,差异有统计学意义(P<0.05)。两组治疗期间均未发生不良反应。结论固本滋阴汤合益气通络汤治疗老年气阴两虚夹瘀证2型糖尿病周围神经病变的效果确切,可以改善临床症状,对周围神经传导速度的恢复具有促进作用,安全性较高,建议临床推广使用。Objective To explore the effect of Guben Ziyin Decoction and Yiqi Tongluo Decoction on elderly patients with type 2 diabetes mellitus peripheral neuropathy with syndrome of deficiency of both qi and yin complicated by stasis.Methods A total of 83 elderly patients with type 2 diabetes mellitus peripheral neuropathy with syndrome of deficiency of both qi and yin complicated by stasis admitted to Jiangyin Hospital of Traditional Chinese Medicine in Jiangsu Province from June 2019 to June 2022 were selected and divided into Mecobalamine group(41 cases,Mecobalamine Tablets)and experimental group(42 cases,on the basis of Mecobalamine group plus Guben Ziyin Decoction and Yiqi Tongluo Decoction)by random number table method.Both groups were treated continuously for two months.Traditional Chinese medicine syndrome score,fasting blood glucose level,nerve conduction velocity,and nerve defect score(NDS)of the two groups before and after treatment were analyzed.The clinical efficacy of the two groups was compared,and the occurrence of adverse reactions during treatment was recorded.Results After treatment,traditional Chinese medicine syndrome scores,NDS,and fasting blood glucose levels of the two groups were lower than those before treatment,the sensory and motor nerve conduction velocity of common peroneal nerve and median nerve was higher than those before treatment,traditional Chinese medicine syndrome scores,NDS,and fasting blood glucose levels of experimental group were lower than those of Mecobalamine group,the sensory and motor nerve conduction velocity of common peroneal nerve and median nerve was higher than those of Mecobalamine group,the differences were statistically significant(P<0.05).The therapeutic effect of experimental group was better than that of Mecobalamine group,and the difference was statistically significant(P<0.05).There was no adverse reaction occurred in both groups during treatment.Conclusion The effect of Gubenziyin Decoction and Yiqi Tongluo Decoction in the treatment of elderly patients with ty

关 键 词：气阴两虚夹瘀证 2型糖尿病 周围神经病变 固本滋阴汤 益气通络汤 

分 类 号：R587.2[医药卫生—内分泌]