清热化痰方在AECOPD患者呼吸功能缓解中的使用价值研究  

The application value of Qingre Huatan Decoction in the remission of respiratory function in AECOPD patients

作　　者：季思勤[1] 姜凤依 盛家刚 杨佩兰[1] 王振伟[1] JI Si-qin;JIANG Feng-yi;SHENG Jia-gang;YANG Pei-lan;WANG Zhen-wei(Department of Respiratory Medicine,Yueyang Integrated Traditional Chinese and Western Medicine Hospital Affiliated to Shanghai University of Traditional Chinese Medicine,Shanghai 200437,China;Department of Gerontology,Yueyang Integrated Traditional Chinese and Western Medicine Hospital Affiliated to Shanghai University of Traditional Chinese Medicine,Shanghai 200437,China)

机构地区：[1]上海中医药大学附属岳阳中西医结合医院呼吸内科,上海200437 [2]上海中医药大学附属岳阳中西医结合医院老年病科,上海200437

出　　处：《川北医学院学报》2023年第3期314-317,共4页Journal of North Sichuan Medical College

基　　金：上海市卫生健康委员会中医药科研项目(2020LP019);上海市卫生健康委员会治未病技术推广项目(YW210.22.2021.01)。

摘　　要：目的:探讨清热化痰方在慢性阻塞性肺疾病急性加重期(AECOPD)患者呼吸功能缓解中的使用价值。方法:选取96例AECOPD患者按照治疗方案不同分为对照组和观察组,每组各48例。对照组采用常规西药治疗,观察组在对照组基础上采用清热化痰方治疗。评估两组的呼吸功能[自我评估测试问卷(CAT)、改良版英国医学研究会呼吸困难量表(mMRC)]、血气分析指标[pH值、动脉血氧分压(PaO_(2))、动脉血二氧化碳分压(PaCO_(2))、血氧饱和度(SpO_(2))]、呼吸肌疲劳指标[呼吸肌功能指标最大吸气口腔压(MIP)]及肺功能指标[用力肺活量(FVC)、第1 s用力呼气容积(FEV1)、第1 s用力呼气容积占预计值百分比(FEV1%)、最大呼气中期流量(MMEF)、每分钟最大通气量(MVV)]。结果:治疗后,观察组患者CAT得分、mMRC评分、PaCO_(2)水平均低于对照组(P<0.05);pH值、PaO_(2)、SpO_(2)水平均高于对照组(P<0.05);MIP、FVC、FEV1、FEV1%、MMEF、MVV水平均高于对照组(P<0.05)。结论:清热化痰方可以改善AECOPD患者的呼吸功能和血气分析指标,提高患者的肺功能,缓解患者的呼吸肌疲劳,在临床医学中具有较高的实用价值。Objective:To explore the application value of Qingre Huatan Decoction in relieving respiratory function of patients with acute exacerbation of chronic obstructive pulmonary disease(AECOPD).Methods:96 patients with AECOPD were divided into the control group and the observation group according to the treatment plan,with 48 patients in each group.The control group was treated with conventional western medicine,and the observation group was treated with Qingre Huatan Decoction based on the control group.The respiratory function[self-assessment test questionnaire(CAT),the modified British Medical Research Association Dyspnea Scale(mMRC)],blood gas analysis indicators[including pH value,arterial partial pressure of oxygen(PaO_(2)),arterial partial pressure of carbon dioxide(PaCO_(2)),and blood oxygen saturation(SpO_(2))],Respiratory muscle fatigue index[including respiratory muscle function index maximum inspiratory oral pressure(MIP)],and pulmonary function index[forced vital capacity(FVC),forced expiratory volume in the first second(FEV1),forced expiratory volume in the first second(FEV1%),maximum mid expiratory flow(MMEF),and maximum ventilation volume per minute(MVV)]of the two groups were evaluated.Results:After treatment,the CAT score,mMRC score and PaCO_(2)level in the observation group were lower than those in the control group(P<0.05).After treatment,the pH value,PaO_(2)and SpO_(2)levels in the observation group were higher than those in the control group(P<0.05).After treatment,the levels of MIP,FVC,FEV1,FEV1%,MMEF and MVV in the observation group were higher than those in the control group(P<0.05).Conclusion:Qingre Huatan Decoction can improve the respiratory function and blood gas analysis index of AECOPD patients,improve the pulmonary function of patients,and relieve the respiratory muscle fatigue of patients.It has high practical value in clinical medicine.

关 键 词：清热化痰方 慢性阻塞性肺疾病 呼吸功能 血气分析 呼吸肌疲劳 肺功能 

分 类 号：R563[医药卫生—呼吸系统]