女性生殖道支原体感染与不孕症的关系及其对阴道微生态的影响  

Relationship between female genital mycoplasma infection and infertility and its effect on vaginal microecology

作　　者：杜娟 刘婷婷 付晴晴[2] DU Juan;LIU Ting-ting;FU Qing-qing(Department of Gynecology,Xudong District,Hubei Provincial Maternal and Child Health Hospital,Wuhan 430070,Hubei,China;Department of Maternal Health,Hubei Provincial Maternal and Child Health Hospital,Wuhan 430070,Hubei,China)

机构地区：[1]湖北省妇幼保健院徐东院区妇科,湖北武汉430070 [2]湖北省妇幼保健院妇保科,湖北武汉430070

出　　处：《川北医学院学报》2023年第3期349-353,共5页Journal of North Sichuan Medical College

基　　金：湖北省卫生健康科研基金(WJ2019H161)。

摘　　要：目的:探讨女性生殖道支原体感染与不孕症的关系及其对阴道微生态的影响。方法:选取198例女性不孕患者为不孕组,同期200名健康体检正常生育女性为对照组,均进行宫颈分泌物支原体检测。比较两组对象生殖道支原体[解脲支原体(UU)和人型支原体(MH)]感染情况及支原体感染与未感染者阴道微生态菌落构成;实时荧光定量PCR技术检测支原体拷贝量。结果:不孕组支原体感染率56.57%,高于对照组的26.50%(P<0.05)。其中UU阳性、MH阳性、UU+MH阳性比例分别为41.41%、6.06%、9.09%,高于对照组的20.50%、2.00%、4.00%(P<0.05)。不孕组UU拷贝量、MH拷贝量高于对照组(P<0.05);UU拷贝量、MH拷贝量>10^(6)copies/mL者比例为42.93%、10.10%,高于对照组的12.50%、3.50%(P<0.05)。不孕组继发性不孕者总支原体感染阳性率67.52%,高于原发性不孕者的40.74%(P<0.05);不孕组继发性不孕者UU拷贝量水平高于原发性不孕者(P<0.05),UU拷贝量>10^(6)copies/mL者比例高于原发性不孕者(P<0.05);不孕组生殖道支原体感染女性阴道微生态失衡比例41.07%,高于未感染女性的24.42%(P<0.05)。不孕组生殖道支原体感染女性外阴阴道假丝酵母病及无特殊病原体的阴道微环态衡比例高于细菌性阴道病、滴虫性阴道病、需氧菌阴道病、混合感染比例(P<0.05)。对照组生殖道支原体感染女性阴道微生态失衡比例30.19%,高于未感染女性13.61%(P<0.05);不孕组阴道微生态失衡比例36.87%,高于对照组的18.00%(P<0.05),且感染患者阴道微生态失衡比例为46.43%,高于对照组感染患者的30.19%(P<0.05)。不孕组未感染患者阴道微生态失衡比例为24.42%,高于对照组未感染患者的13.61%(P<0.05)。结论:支原体感染可引起阴道微生态环境失衡,且与女性不孕关系密切;UU是女性不孕的主要致病支原体种属,相较于原发性不孕,继发性不孕女性支原体感染比例更高。Objective:To investigate the effect of female genital tract mycoplasma infection on infertility and its relationship with vaginal microecology.Methods:A total of 198 female infertility patients were selected as the infertility group,and 200 normal fertile women who underwent physical examination during the same period were selected as the control group.Cervical secretions of both groups were tested for mycoplasma,and the infection status of genital tract mycoplasma[Ureaplasma Uticum(UU)and Mycoplasma hominis(MH)]between the two groups were compared,as well as the composition of vaginal microecological colonies between the two groups and the uninfected mycoplasma.The number of copies of mycoplasma was detected by real-time fluorescence quantitative PCR.Results:The infection rate of mycoplasma in infertility group was 56.57%,which was higher than 26.50%in control group(P<0.05).The positive rates of UU,MH and UU+MH were 41.41%,6.06%and 9.09%respectively,which were higher than those in control group(20.50%,2.00%and 4.00%)(P<0.05).The copy volume of UU and MH in the infertility group was higher than that in the control group(P<0.05).The copy volume of UU and MH count>10^(6)copies/mL were 42.93%and 10.10%,respectively,which were higher than those of control group(12.50%and 3.50%,respectively,P<0.05).The positive rate of total mycoplasma infection in secondary infertility group was 67.52%,which was higher than that in primary infertility group(40.74%)(P<0.05).The copy volume of UU in secondary infertility group was higher than that in primary infertility group(P<0.05).The proportion of UU copy volume>10^(6)copies/mL was higher than that of primary infertility(P<0.05).The proportion of vaginal microecological imbalance in infertile women with genital tract mycoplasma infection was 41.07%,which was higher than that in uninfected women(24.42%)(P<0.05).Infertility group genital mycoplasma infection in women vulvovaginal candidiasis and no special pathogen vaginal microenvironment imbalance ratio was higher than that of bact

关 键 词：不孕症 生殖道 支原体感染 阴道微生态 

分 类 号：R711.6[医药卫生—妇产科学]