妊娠高血压综合征产妇胎盘组织中免疫细胞表达水平及其与不良妊娠结局的相关性  

Expression of immune cells in placenta of pregnant women with pregnancy induced hypertension and its relationship with adverse pregnancy outcome

作　　者：钟辉[1] 晋兴林 蒋玉芬[2] 化金金 龙璐雯 马静[1] 倪萍 钟文娜 ZHONG Hui;JIN Xing-lin;JIANG Yu-fen;HUA Jin-jin;LONG Lu-wen;MA Jing;NI Ping;ZHONG Wen-na(Department of Pathology,Huaibei Maternal and Child Health Hospital,Huaibei 235000,Anhui,China;Department of Obstetric,Huaibei Maternal and Child Health Hospital,Huaibei 235000,Anhui,China)

机构地区：[1]淮北市妇幼保健院病理科,安徽淮北235000 [2]淮北市妇幼保健院产科,安徽淮北235000

出　　处：《川北医学院学报》2023年第3期354-357,共4页Journal of North Sichuan Medical College

基　　金：安徽省淮北市科技局市级科研课题(2021HK031)。

摘　　要：目的:探讨妊娠高血压综合征产妇胎盘组织中免疫细胞表达及其与不良妊娠结局的关系。方法:选取100例妊娠高血压孕妇为研究组,同期100例正常妊娠分娩的孕妇为对照组。对比两组胎盘组织中免疫细胞(CD3、CD4、CD8标记T细胞、CD56标记NK细胞、CD68标记巨噬细胞)表达情况。多因素分析免疫细胞表达与分娩结局的关系,采用受试者工作(ROC)曲线分析免疫细胞表达对不良分娩结局的预测价值。结果:两组受试者胎盘底蜕膜免疫细胞CD4水平比较,差异无统计学意义(P>0.05),研究组的CD3、CD8、CD56、CD68表达水平高于对照组(P<0.05)。100例妊娠高血压孕妇中不良分娩结局21例(21.00%)。两组受试者胎盘底蜕膜免疫细胞CD4表达阳性率比较,差异无统计学意义(P>0.05),不良组的CD3、CD8、CD56和CD68阳性率高于对照组(P<0.05)。多因素分析结果显示,CD3、CD8、CD56和CD68均是妊娠结局的独立危险因素(P<0.05)。ROC曲线分析显示,CD3、CD8、CD56和CD68预测不良妊娠结局的曲线下面积(AUC)分别为0.727、0.734、0.753和0.684。结论:妊娠高血压综合征产妇胎盘组织中免疫细胞表达水平异常,其中CD3、CD8、CD56、CD68标记的免疫细胞均高表达,可增加不良妊娠结局风险。Objective:To investigate the expression of immune cells in placental tissue of pregnant women with pregnancy-induced hypertension syndrome and its relationship with adverse pregnancy outcomes.Methods:100 pregnant women with pregnancy-induced hypertension were selected(study group),and 100 pregnant women who gave birth in normal pregnancy during the same period(control group)were selected.The expression of immune cells(CD3,CD4,CD8 labeled T cells,CD56 labeled NK cells,CD68 labeled macrophages)in placental tissues of the two groups were compared.The relationship between immune cell expression and delivery outcome was analyzed by multivariate analysis,and the predictive value of immune cell expression to adverse delivery outcome was analyzed by receiver operating curve(ROC).Results:There was no significant difference in CD4 level of immune cells of decidua placenta between the two groups(P>0.05),and the expression levels of CD3,CD8,CD56 and CD68 in the study group were higher than those in the control group.Among 100 pregnant women with pregnancy-induced hypertension,21 cases(21.00%)had adverse delivery outcomes.There was no significant difference in the positive rate of CD4 expression in immune cells of decidua placenta between the two groups,but the positive rates of CD3,CD8,CD56 and CD68 in the study group were higher than those in the control group(P<0.05).Multivariate analysis showed that CD3,CD8,CD56 and CD68 were independent risk factors for pregnancy outcome(P<0.05).ROC curve analysis showed that the areas under the curve of CD3,CD8,CD56 and CD68 to predict adverse pregnancy outcomes were 0.727,0.734,0.753 and 0.684,respectively.Conclusion:The expression level of immune cells in placental tissues of pregnant women with pregnancy-induced hypertension syndrome was significantly abnormal,among which CD3,CD8,CD56,CD68 labeled immune cells were highly expressed,which could increase the risk of adverse pregnancy outcome.

关 键 词：妊娠高血压 胎盘组织 免疫细胞 妊娠结局 不良妊娠 

分 类 号：R714.24[医药卫生—妇产科学] R473.6[医药卫生—临床医学]