阻塞性睡眠呼吸暂停低通气综合征与代谢性疾病的研究进展  

Research progress of obstructive sleep apnea hypopnea syndrome and metabolic diseases

作　　者：吴仪伟 张珂承 孙运帷 武攸 陈琰[1] WU Yiwei;ZHANG Kecheng;SUN Yunwei;WU You;CHEN Yan(Department of Endocrinology,the Second Hospital of Jilin University,Jilin Province,Changchun130041,China)

机构地区：[1]吉林大学第二医院内分泌科,吉林长春130041

出　　处：《中国医药导报》2023年第8期50-53,共4页China Medical Herald

基　　金：中国博士后科学基金面上项目(2019M651218)。

摘　　要：阻塞性睡眠呼吸暂停低通气综合征(OSAHS)与代谢性疾病如肥胖、2型糖尿病、非酒精性脂肪肝双相相关。近年来,OSAHS发病率持续上升,对患者的身心健康造成严重危害。但在既往研究中,OSAHS与代谢性疾病相关的作用机制不够明确,OSAHS合并代谢性疾病的治疗方法也相对局限。近年来,OSAHS与代谢性疾病成为研究热点,共同发病机制的研究取得重大进展,减重治疗也逐渐被重视。因此,本文从发病率、共同发病机制、治疗等方面就OSAHS与代谢性疾病的关系及其干预的研究进展作一综述,以期对OSAHS合并代谢性疾病患者的临床精准诊疗有所帮助。There is bidirectional association between obstructive sleep apnea hypopnea syndrome(OSAHS)and metabolic diseases such as obesity,type 2 diabetes mellitus,and nonalcoholic fatty liver.In recent years,the incidence rate of OSAHS continues to rise,causing serious harm to both physical and mental health of patients.However,in previous studies,the mechanism of action related to OSAHS and metabolic diseases is not clear enough,and the treatment methods of OSAHS combined with metabolic diseases are also relatively limited.In recent years,OSAHS and metabolic diseases become research hotspots.Significant progress is made in the study of their common pathogenesis,and weight loss treatment is also gain attention.Therefore,this paper reviews the latest advances in the relationship between OSAHS and metabolic diseases and their intervention,from the aspects of incidence rate,common mechanism,treatment and so on,aiming at helping the progress of clinical treatment of metabolic diseases in OSAHS.

关 键 词：阻塞性睡眠呼吸暂停低通气综合征 糖尿病 肥胖 非酒精性脂肪肝 

分 类 号：R58[医药卫生—内分泌]