血浆血管性血友病因子联合简化肺栓塞严重度指数对急性肺血栓栓塞症患者预后的评估价值  

Prognostic value of plasma von Willebrand factor combined with simplified pulmonary embolism severity index in the assessment of patients with acute pulmonary thromboembolism

作　　者：赵界[1] 杨艳[2] 何正光[1] 夏航彪 杜发旺 ZHAO Jie;YANG Yan;HE Zhengguang;XIA Hangbiao;DU Fawang(Department of Respiratory and Critical Care Medicine,Suining Central Hospital,Sichuan Province,Suining629000,China;Department of Rehabilitation Medicine,Suining Central Hospital,Sichuan Province,Suining629000,China)

机构地区：[1]四川省遂宁市中心医院呼吸与危重症医学科,四川遂宁629000 [2]四川省遂宁市中心医院康复医学科,四川遂宁629000

出　　处：《中国医药导报》2023年第8期115-118,123,共5页China Medical Herald

基　　金：四川省卫生和计划生育委员会科研课题(17PJ037)。

摘　　要：目的探讨血浆血管性血友病因子(vWF)联合简化肺栓塞严重度指数(sPESI)对急性肺血栓栓塞症(APTE)预后的评估价值。方法选取2019年1月至2022年5月四川省遂宁市中心医院收治的153例APTE患者,根据30 d存活情况分为死亡组和存活组,检测血浆vWF抗原水平,并计算sPESI。分析影响APTE患者预后的因素及血浆vWF联合sPESI对患者预后的评估价值。结果死亡组年龄大于存活组,咯血、晕厥、心搏骤停、慢性肾功能不全比例和白细胞计数、vWF、sPESI高于存活组(P<0.05)。心搏骤停和vWF、sPESI升高为APTE患者预后的独立危险因素(P<0.05)。血浆vWF联合sPESI评估APTE患者预后的曲线下面积大于二者单独评估(P<0.05)。结论血浆vWF和sPESI均为APTE预后的独立危险因素,二者联合检测可提高预测效能。Objective To investigate the value of plasma von Willebrand factor(vWF)combined with simplified pulmonary embolism severity index(sPESI)in assessing the prognosis of patients with acute pulmonary thromboembolism(APTE).Methods A total of 153 APTE patients admitted to Suining Central Hospital from January 2019 to May 2022 were selected and they were divided into the death group and the survival group according to their 30 day survival.Plasma vWF antigen levels were detected,and sPESI was calculated.The factors affecting the prognosis of APTE patients and the evaluation value of plasma vWF combined with sPESI in the prognosis of patients were analyzed.Results The death group was older than the survival group,and the proportion of hemoptysis,syncope,cardiac arrest,chronic renal insufficiency,and white blood cell count,vWF and sPESI were higher than those in the survival group(P<0.05).Cardiac arrest,elevated vWF,and sPESI were independent risk factors for the prognosis of APTE patients(P<0.05).The area under the curve of plasma vWF combined with sPESI to evaluate the prognosis of APTE patients was larger than that of the two alone(P<0.05).Conclusion Both plasma vWF and sPESI are independent risk factors for the prognosis of APTE,and their combined detection can improve the predictive power.

关 键 词：急性肺血栓栓塞症 预后 血管性血友病因子 简化肺栓塞严重度指数 

分 类 号：R563.5[医药卫生—呼吸系统]