肺组织缺氧时分子变化与机械性窒息死亡死因鉴定研究进展  

Research Progress on Molecular Changes in Pulmonary Hypoxia and Cause of Death Identification in Mechanical Asphyxia

作　　者：吴天璞 马剑龙 廖信彪[3] 张东川 马开军 余彦耿[3] 陈龙[1] WU Tian-pu;MA Jian-long;LIAO Xin-biao;ZHANG Dong-chuan;MA Kai-jun;YU Yan-geng;CHEN Long(Department of Forensic Medicine,School of Basic Medical Sciences,Fudan University,Shanghai 200032,China;Institute of Criminal Science and Technology,Investigation Department of Shenzhen Pub-lic Security Bureau,Key Laboratory of Forensic Pathology,Ministry of Public Security,Shenzhen 518040,Guangdong Province,China;Institute of Forensic Science,Guangdong Provincial Public Security Depart-ment,Key Laboratory of Forensic Pathology,Ministry of Public Security,Guangzhou 510050,China;Shanghai Key Laboratory of Crime Scene Evidence,Institute of Forensic Science,Shanghai Municipal Pub-lic Security Bureau,Shanghai 200083,China)

机构地区：[1]复旦大学基础医学院法医学系,上海200032 [2]深圳市公安局刑事警察支队刑事技术处法医病理学公安部重点实验室,广东深圳518040 [3]广东省公安厅刑事技术中心法医病理学公安部重点实验室,广东广州510050 [4]上海市公安局物证鉴定中心上海市现场物证重点实验室,上海200083

出　　处：《法医学杂志》2023年第1期57-65,共9页Journal of Forensic Medicine

基　　金：国家自然科学基金面上资助项目(81971788,81373242);法医病理学公安部重点实验室开放课题资助项目(GAFYBL202207);上海市刑事科学技术研究院现场物证重点实验室开放课题资助项目(2021XCWZK09)

摘　　要：肺是机体最大的呼吸器官,缺氧时肺组织细胞快速发生损伤性变化,同时激活自救通路,进而引发复杂的生物大分子变化。机械性窒息死亡是由机械性暴力引起的急性呼吸障碍导致的死亡。由于缺乏特异性的尸体内部征象,机械性窒息死亡的精准死因鉴定一直是法医病理鉴定的难点。本文回顾了缺氧条件下肺组织的生物大分子变化,探讨了将这些变化用于机械性窒息死亡精准死因鉴定的可能性,以期为相关研究提供新思路。Lung is the largest organ of the respiratory system.During hypoxia,pulmonary cells undergo rapid damage changes and activate the self-rescue pathways,thus leading to complex biomacromolecule modification.Death from mechanical asphyxia refers to death due to acute respiratory disorder caused by mechanical violence.Because of the absence of characteristic signs in corpse,the accurate identification of mechanical asphyxia has always been the difficulty in forensic pathology.This paper reviews the biomacromolecule changes under the pulmonary hypoxia condition and discusses the possibility of application of these changes to accurate identification of death from mechanical asphyxia,aiming to provide new ideas for related research.

关 键 词：法医病理学 机械性窒息 死亡原因 缺氧 肺 综述 

分 类 号：DF795.1[医药卫生—法医学]