JNK信号转导通路与病理性疼痛关系的研究进展  

Research Progress on the Relationship Between JNK Signaling Pathway and Pathological Pain

作　　者：宋昕 王彩霞[2] SONG Xin;WANG Caixia(Inner Mongolia Medical University,Hohhot 010059 China;The Second Affiliated Hospital of Inner Mongolia Medical University,Hohh ot 010000 China)

机构地区：[1]内蒙古医科大学,呼和浩特010059 [2]内蒙古医科大学第二附属医院,呼和浩特010000

出　　处：《内蒙古医学杂志》2022年第12期1470-1473,共4页Inner Mongolia Medical Journal

摘　　要：丝裂原活化蛋白激酶(MAPKs)是广泛表达的丝氨酸(酪氨酸)激酶,在细胞内信号转导通路中起重要作用。近年来研究表明,c-Jun氨基末端激酶(c-Jun N-terminal kinase,JNK)作为MAPKs级联的重要分支之一,在调控病理性疼痛的发生与维持中发挥了关键作用。本文围绕其分子结构和功能、JNK信号转导通路的激活及其在病理性疼痛中的作用机制的最新研究进展进行综述,以期为临床疼痛的预防和治疗提供新思路。Mitogen-activated protein kinases(MAPKs)are ubiquitously expressed serine/tyrosine kinases that play important roles in intracellular signal transduction pathways.Recent studies have shown that the c-Jun N-terminal kinase(JNK)signaling pathway,as one of the important branches of the MAPKs cascade,plays a key role in regulating the occurrence and maintenance of pathological pain.This article reviews the latest research progress on its molecular structure and function,the activation of JNK signal transduction pathway,and its mechanism of action in pathological pain,with a view to providing new ideas for the prevention and treatment of clinical pain.

关 键 词：JNK 信号通路 病理性疼痛 外周敏化 中枢敏化 

分 类 号：R441.1[医药卫生—诊断学]