基于CTA影像数据的个体化颅内动脉瘤栓塞数值模拟研究  

Numerical Simulation Study of Individualized Intracranial Aneurysm Embolization Based on CTA Image Data

作　　者：修云霞 陈广新 樊俊杰[2] 张洋 XIU Yunxia;CHEN Guangxin;FAN Junjie;ZHANG Yang(Department of Laboratory,the Second Affiliated Hospital of Mudanjiang Medical College,Mudanjiang,Heilongjiang Province,157011 China;Mudanjiang Medical College,Mudanjiang,Heilongjiang Province,157011 China)

机构地区：[1]牡丹江医学院附属第二医院检验科,黑龙江牡丹江157011 [2]牡丹江医学院,黑龙江牡丹江157011

出　　处：《世界复合医学》2022年第12期50-55,共6页World Journal of Complex Medicine

基　　金：2019年度黑龙江省省属高校科研基本业务费科研项(2019-KYYWF-1003)。

摘　　要：目的 分析不同栓塞率的动脉瘤血流动力学参数分布特征,探讨不完全栓塞对动脉瘤血液流动的影响和破裂风险机制。方法 应用牡丹江医学院附属红旗医院影像科1例动脉瘤患者的影像数据,构建动脉瘤三维模型,分别为0%栓塞、50%栓塞、100%栓塞,利用ANSYS Fluent软件进行仿真计算,选取4个血流动力学参数即时间平均壁面切应力(Tawss)、时间壁面切应力梯度(Tawssg)、振荡剪切指数(OSI)、粒子迟滞时间(RRT)作为考察指标,分析不同栓塞率对血流动力学指标变化的影响。结果 0%栓塞、50%栓塞、100%栓塞动脉瘤的Tawss、Tawssg分布数值呈现逐渐增大趋势,RRT分布数值呈现降低趋势。0%栓塞与50%栓塞的OSI高于100%栓塞血流震荡性强。结论 栓塞程度对动脉瘤内的血流状态具有一定影响,高栓塞率会降低颅内动脉瘤破裂的危险性;同时,术后血管交叉处的管壁易受损。Objective To analyze the distribution characteristics of hemodynamic parameters of aneurysms with different embolization rates,and to explore the effects of incomplete embolization on blood flow of aneurysms and the rupture risk mechanism.Methods Using the image data of an aneurysm patient from the imaging department of Hongqi Hospital Affiliated to Mudanjiang Medical College,a three-dimensional model of the aneurysm was constructed,which was 0%embolism,50%embolism,and 100%embolism,respectively.The simulation calculation was carried out using ANSYS Fluent software.Four hemodynamic parameters,namely timeaverage wall shear stress(Tawss),timewall shear stress gradient(Tawssg),oscillatory shear index(OSI),and relative retention time(RRT),were selected as the evaluation indicators,to analyze the influence of different embolism rates on hemodynamic indexes.Results The Tawss and Tawssg distribution values of 0%embolic,50%embolic and 100%embolic aneurysms gradually increased,while the RRT distribution values decreased.Compared with 100%embolization,0%embolization and 50%embolization have higher OSI and stronger blood flow turbulence.Conclusion The degree of embolism has a certain influence on the blood flow state in the aneurysm,and high embolism rate will reduce the risk of intracranial aneurysm rupture;at the same time,the wall at the intersection of blood vessels is easily damaged after operation.

关 键 词：颅内动脉瘤 栓塞手术 数值模拟 血流动力学参数 

分 类 号：R4[医药卫生—临床医学]