推拿手法对阿片类药物成瘾后焦虑症及γ-氨基丁酸表达水平的影响  

Influence of massage manipulation on anxiety disorder andγ-aminobutyric acid expression level after opioid addiction

作　　者：李淑秀 师宁宁[2] LI Shuxiu;SHI Ningning(College of Acupuncture,Moxibustion,and Massage,Gansu University of Chinese Medicine,Gansu Province,Lanzhou 730000,China;Department of Massage,Gansu Provincial Hospital of Traditional Chinese Medicine,Gansu Province,Lanzhou 730050,China)

机构地区：[1]甘肃中医药大学针灸推拿学院,甘肃兰州730000 [2]甘肃省中医院推拿科,甘肃兰州730050

出　　处：《中国医药导报》2023年第7期93-96,共4页China Medical Herald

基　　金：国家重点研发项目(2018YFC0807400)。

摘　　要：目的探究推拿手法对阿片类药物成瘾后焦虑症及γ-氨基丁酸表达水平的影响。方法选取2020年7月至2021年1月进入甘肃省女子强制隔离戒毒所和兰州市强制隔离戒毒所同一脱毒阶段的药物成瘾后焦虑症患者74例,运用随机数字表法将其分为常规戒毒组37例和推拿手法组37例,干预时间均为3个月。比较两组临床疗效。比较干预前后两组汉密尔顿焦虑量表(HAMA)总分、躯体性焦虑因子评分、精神性焦虑因子评分、γ-氨基丁酸水平的差异。结果研究过程中常规戒毒组中途退出1例。推拿手法组临床疗效优于常规戒毒组,差异有统计学意义(P<0.05)。治疗后,两组HAMA总分、躯体性焦虑评分、精神性焦虑评分均低于治疗前,且推拿手法组低于常规戒毒组,差异有统计学意义(P<0.05)。治疗后,推拿手法组γ-氨基丁酸水平高于本组治疗前,差异有统计学意义(P<0.05)。结论中医推拿可激活阿片类药物成瘾焦虑症患者内源性神经递质γ-氨基丁酸的表达,缓解其焦虑症状,降低对药物的渴求。Objective To explore the influence of massage manipulation on anxiety disorder andγ-aminobutyric acid expression level after opioid addiction.Methods From July 2020 to January 2021,74 patients with post-addiction anxiety disorder entered the Gansu Women’s Compulsory Isolation Drug Rehabilitation Center and Lanzhou Compulsory Isolation Drug Rehabilitation Center at the same detoxication stage were selected and divided into routine detoxification group(37 cases)and massage manipulation group(37 cases)by random number table method.The intervention time was three months.The clinical efficacy of two groups was compared.The Hamilton anxiety scale(HAMA)scale score,somatic anxiety factor score,mental anxiety factor score,andγ-aminobutyric acid level were analyzed and compared between the two groups before and after the intervention.Results One case dropped out of the routine detoxification group during the study.The clinical effect of massage manipulation group was better than that of routine detoxification group,and the difference was statistically significant(P<0.05).After treatment,the HAMA total score,somatic anxiety score,and mental anxiety score of the two groups were lower than those before treatment,and the massage manipulation group was lower than the conventional detox group,the differences were statistically significant(P<0.05).After treatment,the level ofγ-aminobutyric acid in massage manipulation group was higher than that in massage manipulation group before treatment,and the difference was statistically significant(P<0.05).Conclusion Chinese massage can activate the expression of endogenous neurotransmitterγ-aminobutyric acid in patients with opioid addiction anxiety disorder,relieve their anxiety symptoms and reduce the desire for drugs.

关 键 词：推拿 Γ-氨基丁酸 焦虑症 阿片类药物成瘾 

分 类 号：R244.1[医药卫生—针灸推拿学]