人乳源外泌体对新生儿坏死性小肠结肠炎治疗潜力的研究进展  

Progress in therapeutic potential of human breast milk-derived exosomes in neonate necrotizing enterocolitis

作　　者：张睿 朱雪萍[1] Zhang Rui;Zhu Xueping(Department of Neonatology,Children's Hospital of Soochow University,Suzhou 215000,China)

机构地区：[1]苏州大学附属儿童医院新生儿科,苏州215000

出　　处：《中华围产医学杂志》2023年第3期254-257,共4页Chinese Journal of Perinatal Medicine

基　　金：国家自然科学基金(81971423)。

摘　　要：新生儿坏死性小肠结肠炎(neonatal necrotizing enterocolitis,NEC)是新生儿死亡的重要原因之一,目前尚缺乏有效的治疗药物,而母乳喂养是NEC安全有效的预防措施。人乳源外泌体是母乳中的膜性囊泡,有抑制炎症反应、抗氧化应激、调节免疫应答、促进肠上皮增殖与迁移、维持肠道上皮紧密连接等功能,在维持肠道屏障完整性和促进肠道上皮损伤修复方面发挥重要作用。Neonatal necrotizing enterocolitis(NEC)is one of the leading causes of neonatal death and no effective therapeutic drugs are currently available.Breastfeeding is a safe and effective preventive measure for NEC.Human breast milk-derived exosomes(HM-exos),which are membranous vesicles in breast milk,play an important role in maintaining the integrity of the intestinal barrier and promoting the repair of intestinal epithelial cells(IECs)damage through protecting IECs from oxidative stress,improving the proliferation and migration of IECs,maintaining the tight connection between IECs,inhibiting inflammatory response and regulating immune response.

关 键 词：小肠结肠炎 坏死性 乳 人 外泌体 婴儿 新生 

分 类 号：R722.1[医药卫生—儿科]