西咪替丁、赛庚啶、地塞米松三药联合口服治疗带状疱疹后神经痛疗效分析  

Combination of oral cimetidine, cyproheptadine and dexamethasone in the treatment of patients with postherpetic neuralgia

作　　者：王艳青[1] 吴媛[1] 王艳[1] 奚志琴[1] Wang Yanqing;Wu Yuan;Wang Yan;Xi Zhiqin(Department of Dermatology,Second Hospital of Shanxi Medical University,Taiyuan City,Shanxi Province 030001,China)

机构地区：[1]山西医科大学第二医院皮肤科,太原市030001

出　　处：《中华疼痛学杂志》2022年第6期814-819,共6页Chinese Journal Of Painology

摘　　要：目的:探讨西咪替丁、赛庚啶、地塞米松三药联合治疗带状疱疹后神经痛的疗效。方法:收集2014年1月至2020年12月期间,就诊于山西医科大学第二医院皮肤科门诊的带状疱疹后神经痛患者125例,采用随机数字表法随机分为西咪替丁联合组和普瑞巴林组。西咪替丁联合组给予西咪替丁、赛庚啶和地塞米松口服;普瑞巴林组给予普瑞巴林口服。两组同时给予维生素B 1、B 12口服治疗。所有患者在治疗前、治疗后2周和1个月时,采用数字疼痛等级评分(NRS)、疼痛缓解度与镇痛效果、睡眠质量评分,进行疗效评价,并观察不良反应。 结果:两组间的NRS评分比较,在治疗后2周和1个月时,西咪替丁联合组的NRS评分降低明显优于普瑞巴林组,两组差异有统计学意义。两组疼痛缓解度比较,西咪替丁联合组均高于普瑞巴林组,差异有统计学意义;两组睡眠改善情况比较,在治疗后2周和1个月时,西咪替丁联合组优于普瑞巴林组,差异有统计学意义。总有效率和优效率两组比较,治疗后2周时,西咪替丁联合组均高于普瑞巴林组,差异均有统计学意义;治疗后1个月时,两组患者总有效率差异无统计学意义,但优效率西咪替丁联合组优于普瑞巴林组( P<0.001)。 结论:西咪替丁、赛庚啶、地塞米松三药联合口服治疗带状疱疹后神经痛的疗效优于单纯口服普瑞巴林,且副作用少。Objective To analyze the effect of combination of oral cimetidine,cyproheptadine and dexamethasone in the treatment of patients with postherpetic neuralgia(PHN).Methods From January 2014 to December 2020,a total of 125 patients with PHN admitted to the Outpatient Department of Dermatology,Second Hospital of Shanxi Medical University,were enrolled in this study.The patients were randomly divided into cimetidine combined group and pregabalin group by random number table.The patients were given orally cimetidine,cyproheptadine and dexamethasone in the cimetidine combined group;and pregabalin in the pregabalin group.Vitamin B,and Br2 were given in both groups.Efficacy analyses were performed by NRS,pain relief and Sleep quality score at 2 weeks and 1 month after the treatment,and the adverse reactions were observed in the two groups.Results The NRS score was significantly lower in the cimetidine combined group than that in the pregabalin group,with statistical difference at 2 weeks and 1 month after the treatment.The pain relief was higher and the sleep improvement was better in the cimetidine combined group than those in the pregabalin group at 2 weeks and 1 month after the treatment.The total and excellent effective rates were higher in the cimetidine combined group than those in the pregabalin group at 2 weeks after the treatment with statistical significance.The excellent effective rate was better in the cimetidine combined group than that in the pregabalin group(P<0.001),but total effective rate had no statistical significance between the two groups at 1 month after the treatment.Conclusion The effect of combination of oral cimetidine,cyproheptadine and dexamethasone is better than pregabalin alone in the treatment of patient with PHN,with fewer side effects.

关 键 词：神经痛 带状疱疹后 普瑞巴林 西咪替丁 赛庚啶 地塞米松 

分 类 号：R752.12[医药卫生—皮肤病学与性病学]