肠道菌群紊乱与神经病理性疼痛中的病理生理作用的研究进展  

Research progress of intestinal dysbiosis and neuropathic pain

作　　者：侯千暠 钱淑雯 师浩兵 方洪伟 张金源 王祥瑞 廖丽君 Hou Qianhao;Qian Shuwen;Shi Haobing;Fang Hongwei;Zhang Jinyuan;Wang Xiangrui;Liao Lijun(Department of Anesthesiology,Dongfang Hospital Affiliated to Tongji University,Shanghai City 200121,China;Department of Pain Medicine,Dongfang Hospital Affiliated to Tongji University,Shanghai City 200121,China)

机构地区：[1]同济大学附属东方医院麻醉科,上海市200121 [2]同济大学附属东方医院疼痛科,上海市200121

出　　处：《中华疼痛学杂志》2022年第6期837-840,共4页Chinese Journal Of Painology

基　　金：国家自然科学基金面上项目(81971814);上海市浦江人才计划(2020PJD050);浦东新区卫生系统学科带头人培养计划项目(PWRd2020-06)。

摘　　要：神经病理性疼痛(NP)的发病机制仍不清楚。近年来,肠-脑轴紊乱是NP病理机制的研究热点,尤其是肠道菌群紊乱与宿主的免疫调控、神经递质的生成与释放、神经胶质细胞的稳定以及情绪的调节等均密切相关。本文就肠道菌群紊乱在NP中的病理生理作用的最新进展做一综述。The pathogenesis of neuropathic pain(NP)is still unclear.In recent years,gut-brain axis disorder is a research hotspot in the pathological mechanism of NP,and especially the intestinal dysbiosis is closely associated with the immune regulation of the host,the production and release of neurotransmitters,the stability of glial cells and the regulation of emotions.This paper reviewed the latest research progress of intestinal dysbiosis in the pathological role in NP.

关 键 词：神经痛 肠道菌群 肠-脑轴 免疫系统 神经递质 

分 类 号：R614[医药卫生—麻醉学]