单纯疱疹病毒Ⅰ型与阿尔茨海默病相关性及中药抗单纯疱疹病毒Ⅰ型感染研究进展  

Research progress in correlations between herpes simplex virus-1 and Alzheimer’s disease and in the prevention and treatment of herpes simplex virus-1 with traditional Chinese medicine

作　　者：李舒冉 郭姗姗[1] 崔晓兰[1] LI Shuran;GUO Shanshan;CUI Xiaolan(Institute of Chinese Materia Medica,China Academy of Chinese Medical Sciences,Beijing 100029,China)

机构地区：[1]中国中医科学院中药研究所,北京100029

出　　处：《中国药物警戒》2023年第3期258-261,共4页Chinese Journal of Pharmacovigilance

基　　金：国家自然科学基金资助项目(82141206);中央级公益性科研院所基本科研业务费专项资金资助(ZZ15-YQ-035,ZXKT21031);中国中医科学院科技创新项目(CI2021B015)。

摘　　要：目的对单纯疱疹病毒Ⅰ型(herpes simplex virus typeⅠ,HSV-1)与阿尔茨海默病(alzheimer’s disease,AD)的病理关系、可能机制及中药抗HSV-1感染研究进行综述。方法检索CNKI和PubMed数据库,收集1990年1月1日至2022年5月30日中医、西医关于HSV-1与阿尔茨海默病关系研究及中药防治HSV-1研究的报道。结果HSV-1反复感染可诱导β淀粉样蛋白(βamyloid,Aβ)累积和微管相关蛋白磷酸化(Tau protein phosphorylation,p-Tau)表达增加;ApoE4基因有利于HSV-1进入大脑增加HSV-1诱发AD的风险,Aβ可能是一种诱捕HSV-1的抗菌肽;研究发现多种中药单体或复方具有较好的抗HSV-1作用。结论HSV-1感染可能是阿尔茨海默病发生发展的因素之一,其机制可能与Aβ诱捕HSV-1病毒有关,ApoE4基因增加了HSV-1诱发AD的风险,目前中药抗HSV-1感染研究已取得了一定进展,为从中药筛选抗HSV-1新药提供了有力支撑。Objective To review the pathological association between herpes simplex virus type Ⅰ(HSV-1) and Alzheimer’s disease(AD), the possible mechanism and the role of traditional Chinese medicines in anti-HSV-1 infection. Methods CNKI and PubMed databases were searched for reports on the relationships between HSV-1 and Alzheimer’s disease and on the prevention and treatment of HSV-1 with traditional Chinese medicines and Western medicine that were published between January 1, 1990 and May 30, 2022. Results It was found that repeated HSV-1 infections induced the accumulation of β amyloid(Aβ) and the increase of p-Tau expressions. Apo E4 gene facilitated the entry of HSV-1 into the brain and increased the risk of AD induced by HSV-1. Aβ might be an antimicrobial peptide that trapped HSV-1. Many of the monomers or compounds of traditional Chinese medicines had good anti-HSV-1 effect. Conclusion HSV-1 infection maybe one of the factors for the development of Alzheimer’s disease, and the mechanism may be related to the trapping of HSV-1 virus by Aβ. ApoE4 gene increases the risk of HSV-1 induced Alzheimer’s disease. Some progress has been made in the study on anti-HSV-1 infection by traditional Chinese medicines, which provides strong support for screening new drugs against HSV-1 from traditional Chinese medicines.

关 键 词：单纯疱疹病毒I型 阿尔茨海默病 中药 免疫系统 神经系统 感染 

分 类 号：R978.7[医药卫生—药品] R994.11[医药卫生—药学]