地高辛片致男性乳腺增生1例分析  

One case of breast hyperplasia caused by digoxin tablets

作　　者：欧阳荧 钟常歆 夏春华 聂俊刚[1] 周颖 OUYANG Ying;ZHONG Changxin;XIA Chunhua;NIE Jungang;ZHOU Ying(Department of Pharmacy,the First Affiliated Hospital of Nanchang University,Nanchang Jiangxi 330006,China;College of Pharmacy,Nanchang University,Nanchang Jiangxi 330006,China)

机构地区：[1]南昌大学第一附属医院药学部,江西南昌330006 [2]南昌大学药学院,江西南昌330006

出　　处：《中国药物警戒》2023年第3期346-347,359,共3页Chinese Journal of Pharmacovigilance

基　　金：国家自然科学基金资助项目(81903724)。

摘　　要：目的探讨地高辛片导致乳腺增生病例,为临床预防及处理其不良反应提供参考。方法分析1例服用地高辛片导致乳腺增生患者的治疗过程,探讨地高辛片致乳腺增生的机制并排除其他药物的可能性。结果患者服用地高辛后双侧乳腺增生,停用该药并继续服用其他药物治疗1月后,乳房不适减轻。结论地高辛片致乳腺增生或与洋地黄类药物的类雌激素作用有关,用药期间应定期做乳房检查,同时也需防范地高辛片其他严重的不良反应。Objective To study one case of breast hyperplasia induced by digoxin tablets in order to provide reference for clinical prevention and treatment of related adverse reactions.Methods The process of treating one patient who had developed breast hyperplasia after taking digoxin tablets was analyzed.The mechanism by which digoxin tablets caused breast hyperplasia was investigated and the possibility of involvement of other drugs was ruled out.Results The patient had bilateral breast hyperplasia after taking digoxin.After the drug was discontinued and other medications were used for one month,breast discomfort decreased.Conclusion Breast hyperplasia caused by digoxin tablets may be related to the estrogen-like effect of digitalis drugs,so regular breast examination is required during medication.It is also important to guard against other serious adverse reactions caused by digoxin tablets.

关 键 词：地高辛 乳腺增生 乳房发育 雌激素 雄激素 药品不良反应 

分 类 号：R994.11[医药卫生—毒理学]