老年医院获得性肺炎伴心力衰竭患者的生化指标研究  

Study on biochemical indexes of hospital-acquired pneumonia patients with heart failure

作　　者：王琤[1] WANG Cheng(Department of Laboratory,Shenyang 10th People's Hospital,Shenyang 110000,China)

机构地区：[1]沈阳市第十人民医院检验科,110000

出　　处：《中国现代药物应用》2023年第5期70-72,共3页Chinese Journal of Modern Drug Application

摘　　要：目的研究老年医院获得性肺炎(HAP)伴心力衰竭患者的生化指标,旨在寻找评估心功能的敏感标志物。方法选取18例老年HAP伴心力衰竭患者作为观察组,另选取18例老年HAP无心力衰竭症状的患者作为对照组。检测比较观察组与对照组患者心肌损伤标志物[血清天门冬氨酸氨基转移酶(AST)、乳酸脱氢酶(LDH)、肌酸激酶同工酶(CK-MB)、心肌肌钙蛋白I(cTnI)、血清氨基末端脑钠肽前体(NT-proBNP)]水平及观察组心功能Ⅱ~Ⅲ级、Ⅳ级患者的心肌损伤标志物水平。结果观察组患者AST(59.18±19.60)U/L、LDH(461.58±111.20)U/L、CK-MB(53.76±26.30)U/L、cTnI(0.24±0.11)μg/L、NT-proBNP(3253.33±190.00)pg/ml均显著高于对照组的(21.40±11.30)U/L、(122.70±56.30)U/L、(15.40±8.60)U/L、(0.12±0.05)μg/L、(2050.00±160.00)pg/ml,差异有统计学意义(P<0.05)。观察组心功能Ⅱ~Ⅲ级与Ⅳ级患者AST、LDH、CK-MB、cTnI水平比较差异无统计学意义(P>0.05);观察组心功能Ⅳ级患者NT-proBNP(3720.00±180.00)pg/ml显著高于心功能Ⅱ~Ⅲ级患者的(2880.00±120.00)pg/ml,差异有统计学意义(P<0.05)。结论老年HAP伴心力衰竭患者的血清NT-proBNP水平会根据心力衰竭的严重程度发生变化,其可以作为诊断心功能的敏感生化指标,在评估老年HAP伴心力衰竭预后中具有重要的临床价值。Objective To study the biochemical indexes of hospital-acquired pneumonia(HAP)patients with heart failure,so as to find the sensitive indexes to evaluate the cardiac function.Methods 18 elderly patients with HAP and heart failure were selected as the observation group,and 18 elderly patients with HAP and no symptoms of heart failure were selected as the control group.Detection and comparison were made on levels of myocardial injury markers[serum aspartate aminotransferase(AST),lactate dehydrogenase(LDH),creatine kinase isoenzyme(CK-MB),cardiac troponin I(cTnI),serum N-terminal pro-brain natriuretic peptide(NT-proBNP)]between the observation group and the control group,as well as the levels of myocardial injury markers in the patients with cardiac function of gradeⅡ-ⅢandⅣin the observation group.Results The observation group had AST of(59.18±19.60)U/L,LDH of(461.58±111.20)U/L,CK-MB of(53.76±26.30)U/L,cTnI of(0.24±0.11)μg/L,and NT-proBNP of(3253.33±190.00)pg/ml,which were significantly higher than(21.40±11.30)U/L,(122.70±56.30)U/L,(15.40±8.60)U/L,(0.12±0.05)μg/L,and(2050.00±160.00)pg/ml in the control group,and the differences were statistically significant(P<0.05).There was no statistically significant difference in AST,LDH,CK-MB and cTnI levels between patients with gradeⅡ-Ⅲand gradeⅣcardiac function in the observation group(P>0.05).The NT-proBNP in patients with cardiac function gradeⅣwas(2880.00±120.00)pg/ml,which was significantly higher than that of(3720.00±180.00)pg/ml in patients with gradeⅡ-Ⅲcardiac function,and the difference was statistically significant(P<0.05).Conclusion The serum NT-proBNP level in elderly patients with HAP and heart failure changes according to the severity of heart failure,which can be used as a sensitive biochemical indicator in the diagnosis of heart function,and is of great clinical value in evaluating the prognosis of HAP with heart failure in the elderly.

关 键 词：医院获得性肺炎 心力衰竭 老年 N末端脑钠肽前体 

分 类 号：R563.1[医药卫生—呼吸系统] R541.6[医药卫生—内科学]