左西孟旦治疗心肌梗死伴心衰患者的疗效观察  

Efficacy observation of levosimendan for patients with myocardial infarction and heart failure

作　　者：高伟 GAO Wei(People's Hospital of Xiajin County,Dezhou 253200,China)

机构地区：[1]山东省德州市夏津县人民医院,253200

出　　处：《中国现代药物应用》2023年第5期95-97,共3页Chinese Journal of Modern Drug Application

摘　　要：目的探析心肌梗死伴心力衰竭(心衰)患者应用左西孟旦治疗的临床效果。方法84例心肌梗死伴心衰患者,随机分为对照组和观察组,每组42例。观察组患者给予左西孟旦注射液治疗,对照组患者给予多巴酚丁胺治疗。比较两组患者治疗前后心功能指标[左室收缩末期内径(LVESD)、左室舒张末期内径(LVEDD)、左室射血分数(LVEF)]水平及治疗期间不良反应发生情况。结果治疗前,两组患者LVESD、LVEDD、LVEF水平比较差异无统计学意义(P>0.05);治疗后,观察组患者的LVEDD(50.63±2.26)mm、LVESD(39.97±0.43)mm均小于对照组的(57.38±3.43)、(45.38±3.03)mm,LVEF(49.22±4.11)%高于对照组的(40.63±3.14)%,差异有统计学意义(P<0.05)。观察组患者的药物不良反应发生率4.76%低于对照组的19.05%,差异具有统计学意义(P<0.05)。结论心肌梗死伴心衰患者采用左西孟旦治疗能有效改善心功能,安全性高,值得推广。Objective To investigate the clinical effect of levosimendan for patients with myocardial infarction and heart failure.Methods A total of 84 patients with myocardial infarction and heart failure were randomly divided into a control group and an observation group,with 42 cases in each group.Patients in the observation group were treated with levosimendan injection,and patients in the control group were treated with dobutamine.Both groups were compared in terms of levels of cardiac function indexes[left ventricular end-systolic diameter(LVESD),left ventricular end-diastolic diameter(LVEDD),left ventricular ejection fraction(LVEF)]before and after treatment,and the occurrence of adverse reactions during treatment.Results Before treatment,there was no statistically significant difference in LVESD,LVEDD and LVEF levels between the two groups(P>0.05).After treatment,the LVEDD(50.63±2.26)mm and LVESD(39.97±0.43)mm in the observation group were less than(57.38±3.43)and(45.38±3.03)mm in the control group;the LVEF(49.22±4.11)%in the observation group was higher than(40.63±3.14)%in the control group;the differences were statistically significant(P<0.05).The incidence of adverse drug reactions in the observation group was 4.76%,which was lower than 19.05%in the control group,and the difference was statistically significant(P<0.05).Conclusion Levosimendan can effectively improve cardiac function in patients with myocardial infarction and heart failure with high safety,and is worth popularizing.

关 键 词：左西孟旦 心肌梗死 心力衰竭 心功能 不良反应 

分 类 号：R541.6[医药卫生—心血管疾病] R542.22[医药卫生—内科学]