富含半胱氨酸型酸性糖蛋白在皮肤纤维化疾病中的研究进展  

Research progress on secreted protein acidic and rich in cysteine in skin fibrosis disease

作　　者：李茜 李小静[1] 李心怡[1] LI Qian;LI Xiaojing;LI Xinyi(Department of Plastic Surgery,the First Affiliated Hospital of Anhui Medical University,Hefei,Anhui,230022)

机构地区：[1]安徽医科大学第一附属医院整形外科,安徽合肥230022

出　　处：《实用临床医药杂志》2023年第6期137-140,共4页Journal of Clinical Medicine in Practice

基　　金：2019年度安徽省自然科学基金项目青年项目(1908085QH327)。

摘　　要：皮肤纤维化疾病的主要病理特征是以胶原蛋白为主的细胞外基质(ECM)在真皮内过量沉积,进而导致皮肤的增厚或瘢痕过度增生。皮肤较为典型的纤维化病变有硬皮病、增生性瘢痕和瘢痕疙瘩等。研究发现富含半胱氨酸型酸性糖蛋白(SPARC)在多种纤维化病变组织中均存在过表达的情况。SPARC是一种典型的钙结合基质蛋白,能够调节细胞/ECM的相互作用,并影响细胞对生长因子的反应。本文对SPARC在皮肤纤维化疾病中的研究进展进行综述,以期为SPARC作为减轻纤维化的潜在靶点提供依据。The main pathological feature of skin fibrosis disease is the excessive deposition of extracellular matrix(ECM)dominated by collagen in the dermis,which can lead to skin thickening or hypertrophic scar.Typical fibrotic lesions of the skin include scleroderma,hypertrophic scars and keloids.Studies found that secreted protein acidic and rich in cysteine(SPARC)is overexpressed in various fibrotic tissues.SPARC is a typical calcium binding matrix protein that can regulate interactions between cells and ECM,and affect responses of cells to growth factors.This study reviewed the research progress of SPARC in skin fibrosis so as to provide evidence for SPARC as a potential target for alleviating fibrosis.

关 键 词：富含半胱氨酸型酸性糖蛋白 纤维化 细胞外基质 硬皮病 增生性瘢痕 瘢痕疙瘩 

分 类 号：R622[医药卫生—整形外科] R392.1[医药卫生—外科学]