5-羟色胺转运体基因多态性与冠心病患者抑郁风险的荟萃分析  

A systematic review about the relationship between 5-HTTLPR polymorphism and the risk of depression in patients with coronary heart disease

作　　者：李恒立 王路[1] 徐勇 LI Heng-li;WANG Lu;XU Yong(The First People's Hospital of Nanyang,Nanyang,Henan,473000,China)

机构地区：[1]南阳市第一人民医院心内科,河南南阳473000

出　　处：《新疆医学》2023年第1期21-24,共4页Xinjiang Medical Journal

基　　金：河南省医学科技攻关计划(联合共建)(项目编号:LHGJ20190502);南阳市科技计划(项目编号:KJGG123)。

摘　　要：目的 评估5-羟色胺转运体基因多态性与冠心病患者的抑郁风险的关系,以期为临床实践提供依据。方法 计算机检索PubMed、EMBASE、Web of Science、Cochrane、Springer、Sciencedirect、OVID、EBSCO循证医学数据库、中国生物医学文献数据库、中国知网、万方、中文科技期刊全文数据库并辅以手工检索,检索时限为建库至2020年5月发表的相关文章。结果 纳入6项研究,冠心病患者5-HTT基因多态性与抑郁风险之间存在显着相关性(S vs. L:OR=1.29,95%CI=1.16-1.44,P <0.001;Ls vs. LL:OR=1.46,95%CI=1.25-1.69,P <0.001;SS vs. LL:OR=1.66,95%CI=1.29-2.14,P <0.001;LS+SS vs. LL:OR=1.55,95%CI=1.29-1.86,P <0.001;SS vs. LL+LS:OR=1.29,95%CI=1.12-1.50,P <0.001;SS vs. LS:OR=1.20,95%CI=1.04-1.39,P=0.015)。亚组分析结果与总体分析相似,在亚洲人种(S vs L:OR=1.38,95%CI=1.10-1.72,P=0.005;SS vs LL:OR=1.92,95%CI=1.15-3.20,P=0.013;SS vs LL+LS:OR=1.43,95%CI=1.09-1.87,P=0.013;SS vs LS:OR=1.34,95%CI=1.04-1.73,P=0.025)和白种人(LS vs LL:OR=1.71,95%CI=1.06-2.75,P=0.005;LS+SS vs LL:OR=1.70,95%CI=1.07-2.69,P=0.025)观察到显着的相关性。结论 5-HTT基因多态性与冠心病患者的抑郁风险相关,亚洲人和白人的冠心病患者均存在5-HTT多态性与抑郁风险相关,且S等位基因携带者更易患抑郁症。Objective To systematically evaluate the relationship between serotonin transporter gene polymorphism and the risk of depression in patients with coronary heart disease, and to draw a basis on clinical practice. Methods All relevant published paper from the establishment of the database to May 2020 were retrieved and supplemented by manual searchfrom PubMed, EMBASE, web of Science, Cochrane, springer, sciencedirect, OVID, EBSCO evidence-based medicine database, Chinese Biomedical Literature Database,Chinese Journal Full-text Database, CNKI, Wanfang, and Chinese full-text database of scientific and technical journals, VIP database.Results 6 studies were included, and the results showed there was a significant correlation between 5-HTT gene polymorphism and the risk of depression in patients with coronary heart disease(S vs. L:OR = 1.29, 95%CI = 1.16-1.44, P < 0.001;Ls vs. LL:OR = 1.46, 95%CI = 1.25-1.69, P < 0.001;SS vs. LL:OR = 1.66, 95%CI = 1.29-2.14, P < 0.001;LS + SS vs. LL:OR = 1.55, 95%CI = 1.29-1.86, P <0.001;SS vs. LL + LS:OR = 1.29, 95%CI = 1.12-1.50, P < 0.001;SS vs. LS:OR = 1.20, 95%CI = 1.04-1.39, P = 0.015). The results of the subgroup were similar to the overall results. Asian people and white people had been observedsignificant correlation. The data were(S vs L:OR = 1.38, 95%CI = 1.10-1.72, P = 0.005;SS vs LL:OR = 1.92, 95%CI = 1.15-3.20, P = 0.013;SS vs LL + LS:OR = 1.43, 95%CI =1.09-1.87, P = 0.013;SS vs LS:OR = 1.34, 95%CI = 1.04-1.73, P = 0.025)and(LS vs LL:OR = 1.71, 95%CI = 1.06-2.75, P = 0.005;LS + SS vs LL:OR = 1.70, 95%CI = 1.07-2.69, P = 0.025), respectively. Conclusion 5-HTT gene polymorphisms are associated with the risk of depression in patients with coronary heart disease. Both Asian and white patients with coronary heart diseasehave 5-HTT polymorphisms associated with the risk of depression, and Sallele carriers are more likely to suffer from depression.

关 键 词：5-羟色胺转运体基因多态性 抑郁症 冠心病 荟萃分析 

分 类 号：R541[医药卫生—心血管疾病]