点阵式CO_(2)激光与聚焦超声及单纯药物治疗外阴白色病变的对照研究  

Comparative analysis of fractional CO_(2)laser,focused ultrasound and simple drug treatment of gynecological vulva white lesions

作　　者：蒲腾达 曾卉 王俪桦 区淑燕 Pu Tengda;Zeng Hui;Wang Lihua;Qu Shuyan(Department of Gynecology,Hainan Cancer Hospital,Haikou 570100,China;Department of Gynecology,Jiangmen Maternity and Child Health Care Hospital,Jiangmen 529000,China)

机构地区：[1]海南省肿瘤医院妇科,海口570100 [2]江门市妇幼保健院妇科,江门529000

出　　处：《中国医师杂志》2023年第3期406-410,共5页Journal of Chinese Physician

摘　　要：目的探讨点阵式CO_(2)激光与聚焦超声及单纯药物治疗妇科外阴白色病变的效果。方法选取2018年8月至2020年12月期间海南省肿瘤医院收治的妇科外阴白色病变患者126例开展前瞻性研究,采用随机数字表法将其分为药物组、聚焦超声组和点阵式CO_(2)激光组,每组各42例,药物组采用糠酸莫米松乳膏或醋酸地塞米松乳膏治疗,聚焦超声组采用聚焦超声治疗,点阵式CO_(2)激光组采用点阵式CO_(2)激光治疗。比较三组患者治疗前后的血清白介素-2(IL-2)、肿瘤坏死因子-α(TNF-α)、C反应蛋白(CRP)、人体表皮生长因子(EGF)水平以及三组的视觉模拟疼痛评分量表(VAS)、皮肤病生活质量指数(DLQI)评分。结果治疗前,三组的IL-2、TNF-α、CRP、EGF水平差异均无统计学意义(均P>0.05),治疗后,三组IL-2、TNF-α、CRP、EGF水平均显著降低,且聚焦超声组、点阵式CO_(2)激光组的IL-2、TNF-α、CRP、EGF水平低于药物组,差异具有统计学意义(均P<0.05)。治疗前,三组的白色病变、干燥瘙痒、性生活痛、皮肤皴裂评分差异均无统计学意义(均P>0.05),治疗后,三组各维度评分均显著下降,且聚焦超声组、点阵式CO_(2)激光组各维度评分均低于药物组,差异有统计学意义(均P<0.05)。治疗前,三组的症状与感受、日常活动、人际关系评分差异无统计学意义(均P>0.05),治疗后,三组各维度评分均显著降低,且聚焦超声组、点阵式CO_(2)激光组各维度评分均低于药物组,差异有统计学意义(均P<0.05)。结论点阵式CO_(2)激光在妇科外阴白色病变治疗中效果显著,能够降低患者体内炎症因子水平,改善疼痛状况,提高生活质量。Objective To investigate the effects of fractional CO_(2)laser,focused ultrasound and simple drug treatment of gynecological vulva white lesions.Methods A prospective study was conducted on 126 patients with white lesions of the vulva admitted to Hainan Cancer Hospital from August 2018 to December 2020.They were divided into drug group,focused ultrasound group and fractional CO_(2)laser group by random number table method,with 42 patients in each group.The drug group was treated with mometasone furoate cream or dexamethasone acetate cream,and the focused ultrasound group was treated with focused ultrasound;the fractional CO_(2)laser group was treated with fractional CO_(2)laser.The serum interleukin-2(IL-2),tumor necrosis factor-α(TNF-α),C-reactive protein(CRP),and human epidermal growth factor(EGF)levels before and after treatment,and Visual Analogue Scale(VAS)and Dermatology Life Quality Index(DLQI)scores of the three groups were compared.Results Before treatment,there was no significant difference in the levels of IL-2,TNF-α,CRP and EGF among the three groups(all P>0.05).After treatment,the levels of IL-2,TNF-α,CRP and EGF in the three groups were significantly decreased,and the levels of IL-2,TNF-α,CRP and EGF in the focused ultrasound group and fractional CO_(2)laser group were lower than those in the drug group,with statistically significant difference(all P<0.05).Before treatment,there was no significant difference in the white lesions,dry pruritus,sexual pain and chapped skin scores of the three groups(all P>0.05);After treatment,scores of all dimensions of the three groups were significantly decreased,and scores of all dimensions of the focused ultrasound group and fractional CO_(2)laser were lower than those of the drug group,with statistical significance(all P<0.05).Before treatment,there was no significant difference in the scores of symptoms and feelings,daily activities and interpersonal relationship of the three groups(all P>0.05);After treatment,scores of all dimensions of the three groups we

关 键 词：糠酸莫米松 醋酸地塞米松 CO_(2)激光 聚焦超声 外阴硬化性苔癣 

分 类 号：R711.72[医药卫生—妇产科学]