热敏TRPV通道在特应性皮炎温热痒觉异化中的作用  

The role of thermosensitive transient receptor potential vanilloid channel in the dissimilation of itching sensitized by warm in atopic dermatitis

作　　者：赵运升 张慧敏[1] 王东明 Zhao Yunsheng;Zhang Huimin;Wang Dongming(Department of Dermatology,Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine,Shanghai 200126,China;Department of Dermatology,Hangzhou Hospital of Traditional Chinese Medicine,Hangzhou 310007,China)

机构地区：[1]上海中医药大学附属曙光医院皮肤科,上海200126 [2]杭州市中医院皮肤科,杭州310007

出　　处：《中国医师杂志》2023年第3期464-467,共4页Journal of Chinese Physician

基　　金：国家自然科学基金(82104863)。

摘　　要：特应性皮炎(AD)是一种以瘙痒为主要临床特点的炎症性皮肤病。瞬时感受器电位香草酸受体亚型(TRPV)通道可被不同范围的无害温度激活,在AD温热痒觉异化中扮演重要的角色。TRPV通道的抑制剂可以改善或缓解AD症状,可能作为AD治疗的新靶点。本文介绍热敏TRPV通道在AD温热痒觉异化中的作用。Atopic dermatitis(AD)is an inflammatory skin disease characterized by itch.Transient receptor potential vanilloid(TRPV)receptor subtype channel can be activated by different ranges of harmless temperature,and plays an important role in the warm itching in AD.Inhibitors of TRPV channel can alleviate the symptoms of AD,and may be used as a new target for treatment.This paper introduces the role of thermosensitive TRPV channel in the alienation of itching sensitized by warm in AD.

关 键 词：皮炎 特应性 热敏TRPV通道 瘙痒 

分 类 号：R758.2[医药卫生—皮肤病学与性病学]