帕罗西汀致低钠血症  

Hyponatremia due to paroxetine

作　　者：金星 周华[2] 玉章锋[3] Jin Xing;Zhou Hua;Yu Zhangfeng(Department of Pharmacy,Suzhou Municipal Hospital,Jiangsu Province,Suzhou 215001,China;Department of Neurology,Suzhou Municipal Hospital,Jiangsu Province,Suzhou 215001,China;Department of Emergency Medicine,Suzhou Municipal Hospital,Jiangsu Province,Suzhou 215001,China)

机构地区：[1]苏州市立医院药学部,苏州215001 [2]苏州市立医院神经内科,苏州215001 [3]苏州市立医院急诊医学科,苏州215001

出　　处：《药物不良反应杂志》2023年第3期178-180,共3页Adverse Drug Reactions Journal

基　　金：苏州市科技计划项目(SYS2019093)。

摘　　要：1例44岁男性患者因癫痫长期给予丙戊酸钠片0.2 g口服、2次/d联合卡马西平0.1 g口服、2次/d;因十二指肠球部溃疡长期口服雷贝拉唑钠肠溶片10 mg、1次/d。因疗效不佳抗癫痫药调整为丙戊酸钠缓释片0.5 g口服、2次/d联合左乙拉西坦0.25 g口服、2次/d,同时因抑郁状态给予帕罗西汀20 mg口服、1次/d。用药约3个月后,患者反复出现肢体抽搐,实验室检查示血钠128 mmol/L。给予口服及静脉补钠治疗16 d,但血钠水平始终低于130 mmol/L,考虑患者的低钠血症可能为药物引起。停用帕罗西汀,2 d后患者血钠140 mmol/L。A 44-year-old male patient received sodium valproate tablets 0.2 g and carbamazepine 0.1 g twice daily orally for a long time due to epilepsy,rabeprazole sodium enteric-coated tablets 10 mg once daily orally for a long time due to duodenal ulcer.Due to poor efficacy,the antiepileptic drug was adjusted to sodium valproate sustained-release tablets 0.5 g orally twice daily in combination with levetiracetam 0.25 g orally twice daily,and paroxetine 20 mg orally once daily because of depression was given at the same time.After about 3 months of treatments,the patient repeatedly suffered from limb convulsions,and the laboratory test showed serum sodium 128 mmol/L.Oral and intravenous sodium supplementation were given for 16 days,but his blood sodium level was still less than 130 mmol/L.It was considered that the hyponatremia of the patient might be caused by drugs.After stopping paroxetine,the patient′s blood sodium concentration returned to 140 mmol/L 2 days later.

关 键 词：癫痫 帕罗西汀 低钠血症 抗抑郁药 

分 类 号：R969[医药卫生—药理学]