先兆流产保胎治疗中血清指标sHLA-G、IL-17在孕妇妊娠结局中的评估作用分析  

Analysis of the role of serum indicators sHLA-G and IL-17 in the evaluation of pregnant women's pregnancy outcomes in the treatment of threatened abortion

作　　者：洪艳琴 Hong Yanqin(Changsha Fourth Hospital,Changsha,Hunan 410000,China)

机构地区：[1]长沙市第四医院,湖南长沙410000

出　　处：《首都食品与医药》2023年第5期43-45,共3页Capital Food Medicine

摘　　要：目的研究可溶性人类白细胞抗原-G(sHLA-G)、白介素-17(IL-17)评估先兆流产保胎治疗孕妇妊娠结局的效果。方法研究对象为长沙市第四医院2020年1月-2021年12月收治的84例先兆流产保胎治疗患者,所有患者均进行保胎治疗,治疗结束后评估患者妊娠结局,治疗前检测sHLA-G、IL-17及β-人绒毛膜促性腺激素(β-HCG)、孕酮水平。结果84例孕妇中,16例妊娠结局不良(19.05%),68例妊娠结局良好(80.95%);不同妊娠结局孕妇年龄、妊娠前BMI及孕周等一般资料比较,无明显差异(P>0.05);妊娠结局良好孕妇的sHLA-G、β-HCG及孕酮水平高于妊娠结局不良孕妇,IL-17水平低于妊娠结局不良孕妇(P<0.05);先兆流产孕妇孕酮、β-HCG水平与sHLA-G水平为正相关,与IL-17水平为负相关(P<0.05);先兆流产保胎治疗孕妇妊娠结局不良的高危因素是IL-17升高,保护因素是sHLA-G、孕酮、β-HCG水平升高(P<0.05);sHLA-G与IL-17联合应用对先兆流产保胎治疗孕妇妊娠结局不良的预测效果较好。结论sHLA-G、IL-17水平与先兆流产保胎治疗孕妇妊娠结局密切相关,可在一定程度上预测孕妇妊娠结局不良。Objective To study the effect of soluble human leukocyte antigen-G(sHLA-G)and interleukin-17(IL-17)on pregnancy outcomes in pregnant women with threatened abortion.Methods The subjects were 84 patients with threatened abortion treated in our hospital from January 2020 to December 2021.All patients were treated with fetal protection therapy.The pregnancy outcomes were evaluated after treatment,and the levels of sHLA-G,IL-17,β-human chorionic gonadotropin(β-HCG)and progesterone were detected before treatment.Results Among 84 pregnant women,16 cases(19.05%)had poor pregnancy outcome and 68 cases(80.95%)had good pregnancy node.There were no significant differences in age,pre-pregnancy BMI and gestational age among different pregnancy outcomes(P>0.05).The levels of sHLA-G,β-HCG and progesterone in pregnant women with good pregnancy outcomes were higher than those in pregnant women with poor pregnancy outcomes,and the levels of IL-17 were lower than those in pregnant women with poor pregnancy outcomes(P<0.05).The levels of progesterone andβ-HCG were positively correlated with sHLA-G and negatively correlated with IL17(P<0.05).The high risk factors for poor pregnancy outcome of threatened abortion were increased IL-17,and the protective factors were increased levels of sHLA-G,progesterone andβ-HCG(P<0.05).The combination of sHLA-G and IL-17 has a good predictive effect on poor pregnancy outcome in pregnant women with threatened abortion.Conclusion The levels of sHLA-G and IL-17 are closely related to the pregnancy outcomes of pregnant women with threatened abortion and can predict poor pregnancy outcomes to a certain extent.

关 键 词：先兆流产 保胎治疗 妊娠结局 白介素-17 可溶性人类白细胞抗原-G 

分 类 号：R446.1[医药卫生—诊断学]