药学服务对哮喘患儿用药依从性及病情控制影响的meta分析  

Effect of pharmaceutical care on medication adherence and disease control in children with asthma:a meta-analysis

作　　者：刘新 胡利华[2] 尉耘翠 刘小会[2] 马津京[2] 王晓玲[2,3] LIU Xin;HU Li-hua;YU Yun-cui;LIU Xiao-hui;MA Jin-jing;WANG Xiao-ling(School of Medicine,Capital Medical University,Beijing 100069,China;Department of Pharmacy,Beijing Children's Hospital,Capital Medical University,National Center for Children's Health,Beijing 100045,China;Clinical Research Center,Beijing Children's Hospital,Capital Medical University,National Center for Children's Health,Beijing 100045,China)

机构地区：[1]首都医科大学药学院,北京100069 [2]国家儿童医学中心、首都医科大学附属北京儿童医院药学部,北京100045 [3]国家儿童医学中心、首都医科大学附属北京儿童医院临床研究中心,北京100045

出　　处：《临床药物治疗杂志》2023年第2期51-56,共6页Clinical Medication Journal

基　　金：国家呼吸系统疾病临床医学研究中心呼吸专项项目(HXZX-202107)。

摘　　要：目的 评价药师主导的药学服务对支气管哮喘患儿用药依从性及病情控制的影响。方法 检索PubMed、Cochrane Library、Web of Science、Embase、中国知网、万方和维普数据库中药学服务对哮喘患儿用药依从性及疾病控制改善的RCT,检索时限均为建库至2022年3月31日。根据纳入标准和排除标准筛选文献、提取资料,评价纳入研究的方法学质量,应用RevMan 5.4软件进行统计分析。结果 共纳入12篇RCT,包括1455例患儿,meta分析结果显示,药学服务组患儿的用药依从性较对照组有显著提高,差异有统计学意义(RR=1.87,95%CI:1.63~2.15,P<0.01);药学服务组患儿的肺功能[第1秒用力呼气容积占预计值的百分比(FEV1%)](MD=4.92,95%CI:3.67~6.17,P<0.01)和哮喘控制水平(MD=2.43,95%CI:0.69~4.17,P=0.006)均显著优于对照组,差异有统计学意义。结论 药学服务可有效提高哮喘患儿的用药依从性,并对肺功能、哮喘控制和其他临床数据有积极的影响。Objective To evaluate the effectiveness of pharmacist-led pharmaceutical care in the treatment of bronchial asthma in children. Methods Electronic databases such as PubMed, Cochrane Library, Web of Science, Embase, CNKI, Wanfang and VIP databases were searched from inception to March 31,2022. We screened the studies according to the inclusion and exclusion criteria, extracted the data and assessed the quality of the included studies. Meta-analysis was performed using RevMan 5. 4 software. Results A total of 12 RCT were collected, including 1455 children. Meta-analysis showed that there was significant difference in improving medication adherence between pharmaceutical care group and the control group(RR=1. 87, 95%CI: 1. 63 to 2. 15, P<0. 01). In addition, compared to the control group, the pharmaceutical care group statistically improved the pulmonary function of asthmatic children [forced expiratory volume in one second to forced vital capacity ratio(FEV1%)](MD=4. 92, 95%CI: 3. 67 to 6. 17, P<0. 01);and the asthma control level(MD=2. 43, 95%CI: 0. 69 to 4. 17, P=0. 006). Conclusion Pharmaceutical care can effectively improve the medication adherence in asthmatic children, and positively influence pulmonary function, asthma control and other clinical parameters.

关 键 词：药学服务 儿童 支气管哮喘 META分析 随机对照试验 

分 类 号：R95[医药卫生—药学]