可疑头孢哌酮钠舒巴坦钠致药物超敏反应综合征一例  

Suspected cefoperazone sodium and sulbactam sodium-induced drug hypersensitivity syndrome: a case report

作　　者：武霄 张海岳 宋海庆[1] 田飞[1] WU Xiao;ZHANG Hai-yue;SONG Hai-qing;TIAN Fei(Department of Neurology,Xuanwu Hospital Capital Medical University,Beijing 100053,China)

机构地区：[1]首都医科大学宣武医院神经内科,北京100053

出　　处：《临床药物治疗杂志》2023年第2期84-86,共3页Clinical Medication Journal

基　　金：国家重点研发计划(2022YFC3600504)。

摘　　要：本文报告1例患者怀疑头孢哌酮钠舒巴坦钠导致药物超敏反应综合征。73岁男性患者因病毒性脑炎入院后,因肺部感染并发症予静脉泵注头孢哌酮钠舒巴坦钠抗感染治疗,治疗6 d后患者前胸腹部出现散在红斑,皮肤温度升高,停用头孢哌酮钠舒巴坦钠,予抗过敏治疗。最初皮疹数量进行性加重并且范围扩大,间断予皮质类固醇、人免疫球蛋白、抗组胺、保肝及局部外用药等对症支持治疗,患者全身皮疹逐渐消退,随访3个月无复发。对所用药物进行筛选后怀疑头孢哌酮钠舒巴坦钠导致药物超敏反应综合征,不良反应关联性评价结果为可能。本文对该病例药物超敏反应综合征的发生及治疗过程进行梳理,以期为临床合理用药提供参考。A case of drug hypersensitivity syndrome caused by cefoperazone sodium and sulbactam sodium. After the 73-year-old male patient was admitted to hospital for viral encephalitis, he was given intravenous injection of cefoperazone sodium and sulbactam sodium due to complications of pulmonary infection. After 6 days of treatment, the patient appeared scattered erythema in the chest and abdomen, and the skin temperature increased. Cefoperazone sodium and sulbactam sodium was stopped, and anti-allergy treatment was given. However, the number of skin rashes gradually increased and the scope expanded, and the patient was intermittently treated with symptomatic support such as corticosteroids, human immunoglobulin, antihistamine, liver protection and local topical drugs. The patient’s skin rashes gradually subsided, and there was no recurrence after 3 months of follow-up. After screening the drugs used, it is suspected that cefoperazone sodium and sulbactam sodium may cause drug hypersensitivity syndrome, and the adverse reaction correlation evaluation result is possible. This article analyzes the occurrence and treatment of drug hypersensitivity syndrome in this case, so as to provide reference for clinical rational drug use.

关 键 词：头孢哌酮钠舒巴坦钠 头孢类抗菌药物 药物超敏反应综合征 

分 类 号：R969.3[医药卫生—药理学]